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Agfg1 Gene Detail
Summary
  • Symbol
    Agfg1
  • Name
    ArfGAP with FG repeats 1
  • Synonyms
    C130049H11Rik, D730048C23Rik, Hrb, Rip
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333754
    NCBI Gene: 15463
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:82817204-82878903 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 42.55 cM, cytoband C5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1527 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333754
 protein coding gene Chr1:82816738-82878903 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016220
 protein coding gene Chr1:83766338-83829944 (+)
A/J MGP_AJ_G0016203
 protein coding gene Chr1:80795566-80857050 (+)
AKR/J MGP_AKRJ_G0016160
 protein coding gene Chr1:82999117-83064596 (+)
BALB/cJ MGP_BALBcJ_G0016158
 protein coding gene Chr1:80940485-81003627 (+)
C3H/HeJ MGP_C3HHeJ_G0015988
 protein coding gene Chr1:83376367-83438727 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016611
 protein coding gene Chr1:86988270-87065584 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014331
 protein coding gene Chr1:76017848-76085199 (+)
CAST/EiJ MGP_CASTEiJ_G0015574
 protein coding gene Chr1:82786848-82863839 (+)
CBA/J MGP_CBAJ_G0015962
 protein coding gene Chr1:89784312-89853263 (+)
DBA/2J MGP_DBA2J_G0016063
 protein coding gene Chr1:80082465-80144385 (+)
FVB/NJ MGP_FVBNJ_G0016066
 protein coding gene Chr1:79179741-79243535 (+)
LP/J MGP_LPJ_G0016136
 protein coding gene Chr1:84880297-84948025 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016086
 protein coding gene Chr1:93176588-93241795 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016658
 protein coding gene Chr1:83163472-83226948 (+)
PWK/PhJ MGP_PWKPhJ_G0015359
 protein coding gene Chr1:79527037-79594380 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015137
 protein coding gene Chr1:82375094-82445020 (+)
WSB/EiJ MGP_WSBEiJ_G0015634
 protein coding gene Chr1:82959395-83023983 (+)



Homology
more
  • Human Ortholog
    AGFG1, ArfGAP with FG repeats 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGFG1, ArfGAP with FG repeats 1
  • Synonyms
    HRB, RAB, RIP
  • Links
    NCBI Gene ID: 3267
    neXtProt AC: NX_P52594
    UniProt: P52594

  • Chr Location
    2q36.3; chr2:227472152-227561217 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Agfg1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for disruptions in this gene are infertile as a result of abnormalities in spermatogenesis. Otherwise, males and females are normal and live a normal life span.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    14
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026159 Ensembl Gene Model | MGI Sequence Detail 61700 C57BL/6J ±  kb
    transcript ENSMUST00000190046 Ensembl | MGI Sequence Detail 1805 Not Applicable  
    polypeptide ENSMUSP00000140473 Ensembl | MGI Sequence Detail 580 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000003829 Arf-GAP domain and FG repeat-containing protein 1
      (term hierarchy)
    • InterPro Domains
      IPR052248 Arf-GAP domain and FG repeat-containing protein
      IPR038508 ArfGAP domain superfamily
      IPR037278 ARFGAP/RecO-like zinc finger
      IPR001164 Arf GTPase activating protein
    • GlyGen
      Q8K2K6 13 sites, 1 O-linked glycan (13 sites)
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1925111, MGI:2138506, MGI:2138706, MGI:2444445
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:224421 Bryant JM, et al., Characterization of BRD4 during mammalian postmeiotic sperm development. Mol Cell Biol. 2015 Apr;35(8):1433-48
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory