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Cox17 Gene Detail
Summary
  • Symbol
    Cox17
  • Name
    cytochrome c oxidase assembly protein 17, copper chaperone
  • Synonyms
    COX17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333806
    NCBI Gene: 12856
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:38167332-38173125 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 26.77 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    240 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333806
 protein coding gene Chr16:38167332-38182659 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022811
 protein coding gene Chr16:36872507-36878273 (+)
A/J MGP_AJ_G0022776
 protein coding gene Chr16:35043703-35049475 (+)
AKR/J MGP_AKRJ_G0022748
 protein coding gene Chr16:36375162-36380938 (+)
BALB/cJ MGP_BALBcJ_G0022777
 protein coding gene Chr16:35162794-35168581 (+)
C3H/HeJ MGP_C3HHeJ_G0022541
 protein coding gene Chr16:36479358-36485127 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023224
 protein coding gene Chr16:37711689-37717508 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020739
 protein coding gene Chr16:35419146-35425004 (+)
CAST/EiJ MGP_CASTEiJ_G0022067
 protein coding gene Chr16:36634870-36640655 (+)
CBA/J MGP_CBAJ_G0022512
 protein coding gene Chr16:39372431-39378194 (+)
DBA/2J MGP_DBA2J_G0022644
 protein coding gene Chr16:34925093-34931308 (+)
FVB/NJ MGP_FVBNJ_G0022619
 protein coding gene Chr16:34956083-34961854 (+)
LP/J MGP_LPJ_G0022712
 protein coding gene Chr16:36554108-36559875 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022638
 protein coding gene Chr16:38487825-38493580 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023239
 protein coding gene Chr16:36337349-36343413 (+)
PWK/PhJ MGP_PWKPhJ_G0021807
 protein coding gene Chr16:35335598-35341355 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021638
 protein coding gene Chr16:36234434-36240229 (+)
WSB/EiJ MGP_WSBEiJ_G0022111
 protein coding gene Chr16:36407472-36413262 (+)



Homology
more
  • Human Ortholog
    COX17, cytochrome c oxidase copper chaperone COX17
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COX17, cytochrome c oxidase copper chaperone COX17
  • Links
    NCBI Gene ID: 10063
    neXtProt AC: NX_Q14061
    UniProt: Q14061

  • Chr Location
    3q13.33; chr3:119654513-119677454 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a targeted null mutation are growth retarded and die between E8.5 and E10, with severe reductions in cytochrome c oxidase activity at E6.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    103
  • cDNA Data
    76
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12856 NCBI Gene Model | MGI Sequence Detail 5794 C57BL/6J ±  kb
transcript NM_001017429 RefSeq | MGI Sequence Detail 436 Not Specified  
polypeptide P56394 UniProt | EBI | MGI Sequence Detail 63 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005773 cytochrome c oxidase copper chaperone
    (term hierarchy)
  • InterPro Domains
    IPR009069 Cysteine alpha-hairpin motif superfamily
    IPR007745 Cytochrome c oxidase copper chaperone
  • GlyGen
    P56394 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 77
    cDNA 76
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146374
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 4
  • Earliest
    J:51199 Nishihara E, et al., Expression of copper trafficking genes in the mouse brain. Neuroreport. 1998 Oct 5;9(14):3259-63
  • Latest
    J:347290 Guhathakurta S, et al., COX17 acetylation via MOF-KANSL complex promotes mitochondrial integrity and function. Nat Metab. 2023 Nov;5(11):1931-1952
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory