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Cradd Gene Detail
Summary
  • Symbol
    Cradd
  • Name
    CASP2 and RIPK1 domain containing adaptor with death domain
  • Synonyms
    RAIDD
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336168
    NCBI Gene: 12905
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:95010608-95159995 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 49.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4489 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336168
 protein coding gene Chr10:95010601-95160000 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017667
 protein coding gene Chr10:96709194-96865339 (-)
A/J MGP_AJ_G0017646
 protein coding gene Chr10:93305236-93458422 (-)
AKR/J MGP_AKRJ_G0017604
 protein coding gene Chr10:95966750-96130151 (-)
BALB/cJ MGP_BALBcJ_G0017609
 protein coding gene Chr10:93578000-93730051 (-)
C3H/HeJ MGP_C3HHeJ_G0017432
 protein coding gene Chr10:95968537-96126403 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018066
 protein coding gene Chr10:99911595-100080522 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015747
 protein coding gene Chr10:88870877-89028443 (-)
CAST/EiJ MGP_CASTEiJ_G0016997
 protein coding gene Chr10:95981398-96145784 (-)
CBA/J MGP_CBAJ_G0017401
 protein coding gene Chr10:104032493-104211266 (-)
DBA/2J MGP_DBA2J_G0017507
 protein coding gene Chr10:92406963-92557950 (-)
FVB/NJ MGP_FVBNJ_G0017499
 protein coding gene Chr10:91645658-91797459 (-)
LP/J MGP_LPJ_G0017581
 protein coding gene Chr10:97330054-97495696 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017530
 protein coding gene Chr10:105222848-105391971 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018103
 protein coding gene Chr10:95875547-96037784 (-)
PWK/PhJ MGP_PWKPhJ_G0016778
 protein coding gene Chr10:92501024-92660413 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016566
 protein coding gene Chr10:94703281-94868731 (-)
WSB/EiJ MGP_WSBEiJ_G0017056
 protein coding gene Chr10:95848159-96012594 (-)



Homology
more
  • Human Ortholog
    CRADD, CASP2 and RIPK1 domain containing adaptor with death domain
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRADD, CASP2 and RIPK1 domain containing adaptor with death domain
  • Synonyms
    MRT34, RAIDD
  • Links
    NCBI Gene ID: 8738
    neXtProt AC: NX_P78560
    UniProt: P78560

  • Chr Location
    12q22; chr12:93677375-93894840 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CRADD associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    870
  • Tissues
    99
  • cDNA Data
    24
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045867 Ensembl Gene Model | MGI Sequence Detail 149388 C57BL/6J ±  kb
transcript ENSMUST00000053594 Ensembl | MGI Sequence Detail 1661 Not Applicable  
polypeptide ENSMUSP00000050295 Ensembl | MGI Sequence Detail 199 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    Genomic 9
    cDNA 25
    Primer pair 4

    Microarray probesets 5
References
more
  • Summaries
    All 78
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 49
  • Earliest
    J:220665 Bradford GE, Selection for litter size in mice in the presence and absence of gonadotropin treatment. Genetics. 1968 Feb;58(2):283-95
  • Latest
    J:346581 Braun VZ, et al., Extra centrosomes delay DNA damage-driven tumorigenesis. Sci Adv. 2024 Mar 29;10(13):eadk0564
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory