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Kcnab3 Gene Detail
Summary
  • Symbol
    Kcnab3
  • Name
    potassium voltage-gated channel, shaker-related subfamily, beta member 3
  • Synonyms
    C330022D06Rik, Kcnab4, mKv(beta)4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336208
    NCBI Gene: 16499
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69217084-69223867 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.51 cM, cytoband B4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    173 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336208
 protein coding gene Chr11:69217084-69223868 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018527
 protein coding gene Chr11:69748025-69754805 (+)
A/J MGP_AJ_G0018496
 protein coding gene Chr11:67125101-67131881 (+)
AKR/J MGP_AKRJ_G0018465
 protein coding gene Chr11:69124336-69131116 (+)
BALB/cJ MGP_BALBcJ_G0018467
 protein coding gene Chr11:67444067-67450845 (+)
C3H/HeJ MGP_C3HHeJ_G0018280
 protein coding gene Chr11:69148960-69155738 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018919
 protein coding gene Chr11:71860673-71867455 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016563
 protein coding gene Chr11:64055319-64062180 (+)
CAST/EiJ MGP_CASTEiJ_G0017836
 protein coding gene Chr11:69389520-69396309 (+)
CBA/J MGP_CBAJ_G0018254
 protein coding gene Chr11:75076962-75083740 (+)
DBA/2J MGP_DBA2J_G0018363
 protein coding gene Chr11:66719300-66726083 (+)
FVB/NJ MGP_FVBNJ_G0018353
 protein coding gene Chr11:66342714-66349494 (+)
LP/J MGP_LPJ_G0018434
 protein coding gene Chr11:70318355-70325135 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018376
 protein coding gene Chr11:75694783-75701563 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018960
 protein coding gene Chr11:69383554-69390334 (+)
PWK/PhJ MGP_PWKPhJ_G0017611
 protein coding gene Chr11:67359064-67365897 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017399
 protein coding gene Chr11:69206053-69212883 (+)
WSB/EiJ MGP_WSBEiJ_G0017890
 protein coding gene Chr11:69060932-69067712 (+)



Homology
more
  • Human Ortholog
    KCNAB3, potassium voltage-gated channel subfamily A regulatory beta subunit 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNAB3, potassium voltage-gated channel subfamily A regulatory beta subunit 3
  • Synonyms
    AKR6A9, KCNA3.1B, KCNA3B, KV-BETA-3
  • Links
    NCBI Gene ID: 9196
    neXtProt AC: NX_O43448
    UniProt: O43448

  • Chr Location
    17p13.1; chr17:7921859-7929856 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    46
  • cDNA Data
    16
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16499 NCBI Gene Model | MGI Sequence Detail 6784 C57BL/6J ±  kb
    transcript NM_010599 RefSeq | MGI Sequence Detail 2537 C57BL/6  
    polypeptide P97382 UniProt | EBI | MGI Sequence Detail 249 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000009253 voltage-gated potassium channel subunit beta-3
      (term hierarchy)
    • EC
      1.1.1.-
    • InterPro Domains
      IPR023210 NADP-dependent oxidoreductase domain
      IPR036812 NADP-dependent oxidoreductase domain superfamily
      IPR005983 Potassium channel, voltage-dependent, beta subunit, KCNAB
      IPR005402 Potassium channel, voltage-dependent, beta subunit, KCNAB3
      IPR005399 Potassium channel, voltage-dependent, beta subunit, KCNAB-related
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38198, MGI:109154, MGI:2442514
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory