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Slc7a7 Gene Detail
Summary
  • Symbol
    Slc7a7
  • Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
  • Synonyms
    my+lat1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337120
    NCBI Gene: 20540
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:54606899-54655237 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 27.76 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1150 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337120
 protein coding gene Chr14:54606899-54657525 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021307
 protein coding gene Chr14:48309934-48360930 (-)
A/J MGP_AJ_G0021266
 protein coding gene Chr14:47378936-47426606 (-)
AKR/J MGP_AKRJ_G0021242
 protein coding gene Chr14:49092940-49142100 (-)
BALB/cJ MGP_BALBcJ_G0021270
 protein coding gene Chr14:47350346-47398086 (-)
C3H/HeJ MGP_C3HHeJ_G0021050
 protein coding gene Chr14:48774786-48823262 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021709
 protein coding gene Chr14:50770026-50820371 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019253
 protein coding gene Chr14:45798840-45847010 (-)
CAST/EiJ MGP_CASTEiJ_G0020569
 protein coding gene Chr14:45018484-45069091 (-)
CBA/J MGP_CBAJ_G0021017
 protein coding gene Chr14:52266663-52315684 (-)
DBA/2J MGP_DBA2J_G0021138
 protein coding gene Chr14:47124091-47171967 (-)
FVB/NJ MGP_FVBNJ_G0021120
 protein coding gene Chr14:46577864-46625456 (-)
LP/J MGP_LPJ_G0021212
 protein coding gene Chr14:49322283-49372137 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021144
 protein coding gene Chr14:51709927-51761081 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021735
 protein coding gene Chr14:48276115-48324272 (-)
PWK/PhJ MGP_PWKPhJ_G0020315
 protein coding gene Chr14:43649800-43697636 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020143
 protein coding gene Chr14:44268491-44314784 (-)
WSB/EiJ MGP_WSBEiJ_G0020622
 protein coding gene Chr14:48570340-48621432 (-)



Homology
more
  • Human Ortholog
    SLC7A7, solute carrier family 7 member 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC7A7, solute carrier family 7 member 7
  • Synonyms
    LAT3, LPI, MOP-2, y+LAT-1, Y+LAT1
  • Links
    NCBI Gene ID: 9056
    neXtProt AC: NX_Q9UM01
    UniProt: Q9UM01

  • Chr Location
    14q11.2; chr14:22773222-22829820 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slc7a7 mouse models; 1 with human SLC7A7 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 3 alleles in 7 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit fetal growth retardation and often die neonatally. After heavy protein ingestion, surviving adults show a metabolic derangement akin to lysinuric protein intolerance and including a lasting postnatal growth retardation, splenomegaly, hyperammonemia, and aminoaciduria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    4
  • cDNA Data
    12
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000958 Ensembl Gene Model | MGI Sequence Detail 48339 C57BL/6J ±  kb
    transcript ENSMUST00000000984 Ensembl | MGI Sequence Detail 2132 Not Applicable  
    polypeptide ENSMUSP00000000984 Ensembl | MGI Sequence Detail 510 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 12
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145692
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 5
      Phenotypes 17
    • Earliest
      J:51906 Pfeiffer R, et al., Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family. EMBO J. 1999 Jan 4;18(1):49-57
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory