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Bex3 Gene Detail
Summary
  • Symbol
    Bex3
  • Name
    brain expressed X-linked 3
  • Synonyms
    DXWsu67e, Gcap27, Nade, Ngfrap1, p75NTR-associated Cell Death Executor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338016
    NCBI Gene: 12070
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:135171002-135172727 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 57.64 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    92 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338016
 protein coding gene ChrX:135171002-135172727 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036098
 protein coding gene ChrX:133641749-133643272 (+)
A/J MGP_AJ_G0036079
 protein coding gene ChrX:133044145-133044802 (+)
AKR/J MGP_AKRJ_G0036005
 protein coding gene ChrX:137308347-137309793 (+)
BALB/cJ MGP_BALBcJ_G0036067
 protein coding gene ChrX:131426185-131427240 (+)
C3H/HeJ MGP_C3HHeJ_G0035778
 protein coding gene ChrX:133638464-133639516 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036591
 protein coding gene ChrX:137484935-137486103 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033422
 protein coding gene ChrX:125033717-125035354 (+)
CAST/EiJ MGP_CASTEiJ_G0035067
 protein coding gene ChrX:114557642-114558311 (+)
CBA/J MGP_CBAJ_G0035753
 protein coding gene ChrX:141705655-141706707 (+)
DBA/2J MGP_DBA2J_G0035909
 protein coding gene ChrX:132375346-132376862 (+)
FVB/NJ MGP_FVBNJ_G0035844
 protein coding gene ChrX:131558571-131559228 (+)
LP/J MGP_LPJ_G0036004
 protein coding gene ChrX:134563236-134565351 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035879
 protein coding gene ChrX:149092752-149094275 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036629
 protein coding gene ChrX:132992111-132993246 (+)
PWK/PhJ MGP_PWKPhJ_G0034759
 protein coding gene ChrX:111465397-111466054 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034588
 protein coding gene ChrX:115193828-115194497 (+)
WSB/EiJ MGP_WSBEiJ_G0035200
 protein coding gene ChrX:131335361-131336018 (+)



Homology
more
  • Human Ortholog
    BEX3, brain expressed X-linked 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BEX3, brain expressed X-linked 3
  • Synonyms
    Bex, DXS6984E, Hero20, HGR74, NADE, NGFRAP1
  • Links
    NCBI Gene ID: 27018
    neXtProt AC: NX_Q00994
    UniProt: Q00994

  • Chr Location
    Xq22.2; chrX:103376323-103378164 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 3 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit enlarged frontal bone, dilated brain ventricle, increased stereotypic behavior, increased prepulse inhibition, decreased density in motor, cingulate and sensory cortices, and caudate-putamen, decreased total spontaneous activity frequency, and strongly reduced inhibitory postsynaptic current frequency.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    789
  • Tissues
    52
  • cDNA Data
    170
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12070 NCBI Gene Model | MGI Sequence Detail 1726 C57BL/6J ±  kb
    transcript NM_009750 RefSeq | MGI Sequence Detail 939 ZRU/MplStud  
    polypeptide Q9WTZ9 UniProt | EBI | MGI Sequence Detail 124 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 176
      cDNA 170
      Primer pair 5
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-18678, MGD-MRK-33932, MGI:101854, MGI:106240, MGI:2147950
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:19885 Kambouris M, et al., Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library. Brain Res Mol Brain Res. 1994 Sep;25(3-4):183-91
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory