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Mapk11 Gene Detail
Summary
  • Symbol
    Mapk11
  • Name
    mitogen-activated protein kinase 11
  • Synonyms
    P38b, p38beta, Prkm11, Sapk2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338024
    NCBI Gene: 19094
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:89026685-89033809 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 44.66 cM, cytoband E3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    180 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338024
 protein coding gene Chr15:89026685-89033831 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022220
 protein coding gene Chr15:90317124-90324238 (-)
A/J MGP_AJ_G0022179
 protein coding gene Chr15:86866032-86873151 (-)
AKR/J MGP_AKRJ_G0022154
 protein coding gene Chr15:89432332-89439452 (-)
BALB/cJ MGP_BALBcJ_G0022185
 protein coding gene Chr15:86965767-86974463 (-)
C3H/HeJ MGP_C3HHeJ_G0021955
 protein coding gene Chr15:89420407-89427531 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022630
 protein coding gene Chr15:93598563-93605618 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020155
 protein coding gene Chr15:83088993-83096282 (-)
CAST/EiJ MGP_CASTEiJ_G0021477
 protein coding gene Chr15:90204542-90211664 (-)
CBA/J MGP_CBAJ_G0021922
 protein coding gene Chr15:96759511-96766879 (-)
DBA/2J MGP_DBA2J_G0022049
 protein coding gene Chr15:86318669-86325785 (-)
FVB/NJ MGP_FVBNJ_G0022028
 protein coding gene Chr15:85382829-85389942 (-)
LP/J MGP_LPJ_G0022120
 protein coding gene Chr15:90475586-90482700 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022048
 protein coding gene Chr15:101182788-101190168 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022645
 protein coding gene Chr15:89467925-89474902 (-)
PWK/PhJ MGP_PWKPhJ_G0021218
 protein coding gene Chr15:86362484-86369806 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021052
 protein coding gene Chr15:89201588-89208670 (-)
WSB/EiJ MGP_WSBEiJ_G0021526
 protein coding gene Chr15:89956054-89963155 (-)



Homology
more
  • Human Ortholog
    MAPK11, mitogen-activated protein kinase 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAPK11, mitogen-activated protein kinase 11
  • Synonyms
    p38-2, P38B, p38Beta, P38BETA2, PRKM11, SAPK2, SAPK2B
  • Links
    NCBI Gene ID: 5600
    neXtProt AC: NX_Q15759
    UniProt: Q15759

  • Chr Location
    22q13.33; chr22:50263713-50270767 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 8 alleles in 7 genetic backgrounds
    23 phenotypes from multigenic genotypes
    3 images
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    22
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    1
  • Radiation induced
    2
  • Targeted
    15
  • Genomic Mutations
    3 involving Mapk11
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    35 strains or lines available
Mice homozygous for a knock-out allele exhibit a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    812
  • Tissues
    26
  • cDNA Data
    25
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 19094 NCBI Gene Model | MGI Sequence Detail 7125 C57BL/6J ±  kb
transcript NM_011161 RefSeq | MGI Sequence Detail 2452 C57BL/6  
polypeptide Q9WUI1 UniProt | EBI | MGI Sequence Detail 364 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    Genomic 1
    cDNA 25
    Primer pair 1

    Microarray probesets 7
References
more
  • Summaries
    All 106
    Developmental Gene Expression 9
    Diseases 1
    Gene Ontology 12
    Phenotypes 54
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory