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Klf5 Gene Detail
Summary
  • Symbol
    Klf5
  • Name
    Kruppel-like transcription factor 5
  • Synonyms
    4930520J07Rik, Bteb2, CKLF, IKLF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338056
    NCBI Gene: 12224
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:99536127-99550848 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 49.43 cM, cytoband E2.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    359 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338056
 protein coding gene Chr14:99536127-99552472 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021618
 protein coding gene Chr14:95584874-95599588 (+)
A/J MGP_AJ_G0021576
 protein coding gene Chr14:92536274-92550988 (+)
AKR/J MGP_AKRJ_G0021552
 protein coding gene Chr14:95258556-95273308 (+)
BALB/cJ MGP_BALBcJ_G0021582
 protein coding gene Chr14:92871792-92886506 (+)
C3H/HeJ MGP_C3HHeJ_G0021360
 protein coding gene Chr14:95142651-95157365 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022022
 protein coding gene Chr14:99490678-99505392 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019562
 protein coding gene Chr14:89586862-89601787 (+)
CAST/EiJ MGP_CASTEiJ_G0020877
 protein coding gene Chr14:92439642-92456125 (+)
CBA/J MGP_CBAJ_G0021328
 protein coding gene Chr14:103168710-103183461 (+)
DBA/2J MGP_DBA2J_G0021452
 protein coding gene Chr14:92030154-92044889 (+)
FVB/NJ MGP_FVBNJ_G0021429
 protein coding gene Chr14:91069351-91084065 (+)
LP/J MGP_LPJ_G0021520
 protein coding gene Chr14:96384540-96399254 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021456
 protein coding gene Chr14:105889241-105903955 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022045
 protein coding gene Chr14:94769713-94784427 (+)
PWK/PhJ MGP_PWKPhJ_G0020620
 protein coding gene Chr14:89018160-89033003 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020458
 protein coding gene Chr14:90750328-90764972 (+)
WSB/EiJ MGP_WSBEiJ_G0020930
 protein coding gene Chr14:95373175-95387915 (+)



Homology
more
  • Human Ortholog
    KLF5, KLF transcription factor 5
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLF5, KLF transcription factor 5
  • Synonyms
    BTEB2, CKLF, IKLF
  • Links
    NCBI Gene ID: 688
    neXtProt AC: NX_Q13887
    UniProt: Q13887

  • Chr Location
    13q22.1; chr13:73054976-73077541 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    98 phenotypes from 8 alleles in 12 genetic backgrounds
    6 phenotypes from multigenic genotypes
    6 images
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die during gestation, while heterozygotes exhibit abnormal cardiovascular remodeling after external stress. Mice homozygous for a floxed allele activated in the prostate exhibit increased cell proliferation and hyperplasia in the prostate without neoplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    997
  • Tissues
    138
  • cDNA Data
    24
  • Literature Summary
    48
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12224 NCBI Gene Model | MGI Sequence Detail 14722 C57BL/6J ±  kb
    transcript NM_009769 RefSeq | MGI Sequence Detail 1728 C57BL/6  
    polypeptide Q9Z0Z7 UniProt | EBI | MGI Sequence Detail 446 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 25
      Primer pair 7
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1922343
    References
    more
    • Summaries
      All 157
      Developmental Gene Expression 48
      Gene Ontology 14
      Phenotypes 61
    • Earliest
      J:51610 Imhof A, et al., Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/ egr-related zinc finger repressor. Mol Cell Biol. 1999 Jan;19(1):194-204
    • Latest
      J:354191 Kc R, et al., Multimodal Hox5 activity generates motor neuron diversity. Commun Biol. 2024 Sep 17;7(1):1166
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory