About   Help   FAQ
Ikbkb Gene Detail
Summary
  • Symbol
    Ikbkb
  • Name
    inhibitor of kappaB kinase beta
  • Synonyms
    IKK-2, IKK2, IKK[b], IKK-beta, IKKbeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338071
    NCBI Gene: 16150
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:23149228-23196605 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 11.42 cM, cytoband A3-A4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1490 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338071
 protein coding gene Chr8:23149228-23196605 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033457
 protein coding gene Chr8:20519396-20568821 (-)
A/J MGP_AJ_G0033437
 protein coding gene Chr8:19851304-19899773 (-)
AKR/J MGP_AKRJ_G0033362
 protein coding gene Chr8:20503603-20552341 (-)
BALB/cJ MGP_BALBcJ_G0033433
 protein coding gene Chr8:19975406-20022767 (-)
C3H/HeJ MGP_C3HHeJ_G0033147
 protein coding gene Chr8:20703203-20752316 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033949
 protein coding gene Chr8:21387309-21435343 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030902
 protein coding gene Chr8:17180973-17190568 (-)
CAST/EiJ MGP_CASTEiJ_G0032473
 protein coding gene Chr8:20117759-20164994 (-)
CBA/J MGP_CBAJ_G0033122
 protein coding gene Chr8:22243209-22295444 (-)
DBA/2J MGP_DBA2J_G0033277
 protein coding gene Chr8:19816378-19867352 (-)
FVB/NJ MGP_FVBNJ_G0033221
 protein coding gene Chr8:19616506-19663728 (-)
LP/J MGP_LPJ_G0033366
 protein coding gene Chr8:20513282-20562126 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033264
 protein coding gene Chr8:21836992-21885879 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033968
 protein coding gene Chr8:20410881-20458109 (-)
PWK/PhJ MGP_PWKPhJ_G0032185
 protein coding gene Chr8:19404417-19451344 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032018
 protein coding gene Chr8:19787353-19834196 (-)
WSB/EiJ MGP_WSBEiJ_G0032589
 protein coding gene Chr8:20613654-20662929 (-)



Homology
more
  • Human Ortholog
    IKBKB, inhibitor of nuclear factor kappa B kinase subunit beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IKBKB, inhibitor of nuclear factor kappa B kinase subunit beta
  • Synonyms
    IKK-2, IKK2, IKKB, IKK-beta, IMD15, IMD15A, IMD15B, NFKBIKB
  • Links
    NCBI Gene ID: 3551
    neXtProt AC: NX_O14920
    UniProt: O14920

  • Chr Location
    8p11.21; chr8:42271302-42332460 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ikbkb mouse models; 8 with human IKBKB associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    80 phenotypes from 16 alleles in 19 genetic backgrounds
    41 phenotypes from multigenic genotypes
    3 images
    283 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit liver degeneration and die in midgestation. Conditional mutations that lack gene expression in lymphoid cells or epidermal keratinocytes exhibit B and T cell deficits and skin inflammation, respectively.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    101
  • GO References
    36
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    25
  • cDNA Data
    116
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16150 NCBI Gene Model | MGI Sequence Detail 47378 C57BL/6J ±  kb
    transcript NM_010546 RefSeq | MGI Sequence Detail 4503 C57BL/6  
    polypeptide O88351 UniProt | EBI | MGI Sequence Detail 757 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 121
      cDNA 120
      Primer pair 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:2142466
    References
    more
    • Summaries
      All 474
      Developmental Gene Expression 17
      Diseases 2
      Gene Ontology 36
      Phenotypes 283
    • Earliest
      J:54118 Verma IM, et al., Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 1995 Nov 15;9(22):2723-35
    • Latest
      J:355512 Chen Z, et al., Primed inflammatory response by fibroblast subset is necessary for proper oral and cutaneous wound healing. Mol Oral Microbiol. 2024 Jun;39(3):113-124
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory