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Trim10 Gene Detail
Summary
  • Symbol
    Trim10
  • Name
    tripartite motif-containing 10
  • Synonyms
    Herf1, Rnf9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338757
    NCBI Gene: 19824
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:37180466-37188725 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338757
 protein coding gene Chr17:37180388-37188725 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023684
 protein coding gene Chr17:37219310-37228762 (+)
A/J MGP_AJ_G0023642
 protein coding gene Chr17:36049345-36057617 (+)
AKR/J MGP_AKRJ_G0023613
 protein coding gene Chr17:36483438-36491677 (+)
BALB/cJ MGP_BALBcJ_G0023649
 protein coding gene Chr17:36289987-36298242 (+)
C3H/HeJ MGP_C3HHeJ_G0023411
 protein coding gene Chr17:36997224-37005463 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024087
 protein coding gene Chr17:38818271-38826512 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021555
 protein coding gene Chr17:33861955-33872526 (+)
CAST/EiJ MGP_CASTEiJ_G0022896
 protein coding gene Chr17:37125435-37133680 (+)
CBA/J MGP_CBAJ_G0023388
 protein coding gene Chr17:40333321-40341560 (+)
DBA/2J MGP_DBA2J_G0023513
 protein coding gene Chr17:35441278-35449525 (+)
FVB/NJ MGP_FVBNJ_G0023486
 protein coding gene Chr17:35050556-35058800 (+)
LP/J MGP_LPJ_G0023591
 protein coding gene Chr17:37752899-37761141 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023509
 protein coding gene Chr17:39129434-39138584 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024132
 protein coding gene Chr17:36821316-36830633 (+)
PWK/PhJ MGP_PWKPhJ_G0022648
 protein coding gene Chr17:34218468-34226701 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022467
 protein coding gene Chr17:34903276-34912800 (+)
WSB/EiJ MGP_WSBEiJ_G0022963
 protein coding gene Chr17:37136580-37144849 (+)



Homology
more
  • Human Ortholog
    TRIM10, tripartite motif containing 10
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM10, tripartite motif containing 10
  • Synonyms
    HERF1, RFB30, RNF9
  • Links
    NCBI Gene ID: 10107
    neXtProt AC: NX_Q9UDY6
    UniProt: Q9UDY6

  • Chr Location
    6p22.1; chr6:30151943-30164009 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show prevention of transverse aortic constriction-induced cardiac hypertrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    67
  • cDNA Data
    12
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000073400 Ensembl Gene Model | MGI Sequence Detail 8260 C57BL/6J ±  kb
    transcript ENSMUST00000060524 Ensembl | MGI Sequence Detail 2245 Not Applicable  
    polypeptide ENSMUSP00000057928 Ensembl | MGI Sequence Detail 489 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146826, MGI:2147109
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:54633 Harada H, et al., HERF1, a novel hematopoiesis-specific RING finger protein, is required for terminal differentiation of erythroid cells. Mol Cell Biol. 1999 May;19(5):3808-15
    • Latest
      J:348568 Kong L, et al., The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus. Cell Rep. 2023 Mar 26;42(4):112306
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory