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Acvr1b Gene Detail
Summary
  • Symbol
    Acvr1b
  • Name
    activin A receptor, type 1B
  • Synonyms
    ActR-IB, ActRIB, Acvrlk4, Alk4, SKR2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338944
    NCBI Gene: 11479
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:101071953-101111565 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.48 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    649 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338944
 protein coding gene Chr15:101071948-101111565 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022366
 protein coding gene Chr15:103237873-103260497 (+)
A/J MGP_AJ_G0022328
 protein coding gene Chr15:99136856-99176839 (+)
AKR/J MGP_AKRJ_G0022304
 protein coding gene Chr15:102155161-102195672 (+)
BALB/cJ MGP_BALBcJ_G0022332
 protein coding gene Chr15:99256658-99278385 (+)
C3H/HeJ MGP_C3HHeJ_G0022102
 protein coding gene Chr15:102245742-102285897 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022780
 protein coding gene Chr15:107062600-107103707 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020305
 protein coding gene Chr15:94873289-94912257 (+)
CAST/EiJ MGP_CASTEiJ_G0021627
 protein coding gene Chr15:103097912-103137181 (+)
CBA/J MGP_CBAJ_G0022071
 protein coding gene Chr15:110771113-110816249 (+)
DBA/2J MGP_DBA2J_G0022198
 protein coding gene Chr15:98469950-98509169 (+)
FVB/NJ MGP_FVBNJ_G0022177
 protein coding gene Chr15:97516682-97557952 (+)
LP/J MGP_LPJ_G0022269
 protein coding gene Chr15:103376147-103400586 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022198
 protein coding gene Chr15:114489603-114510360 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022794
 protein coding gene Chr15:102200007-102224349 (+)
PWK/PhJ MGP_PWKPhJ_G0021366
 protein coding gene Chr15:98623595-98664383 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021198
 protein coding gene Chr15:102081738-102120221 (+)
WSB/EiJ MGP_WSBEiJ_G0021677
 protein coding gene Chr15:102805930-102847747 (+)



Homology
more
  • Human Ortholog
    ACVR1B, activin A receptor type 1B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACVR1B, activin A receptor type 1B
  • Synonyms
    ACTRIB, ACVRLK4, ALK4, SKR2
  • Links
    NCBI Gene ID: 91
    neXtProt AC: NX_P36896
    UniProt: P36896

  • Chr Location
    12q13.13; chr12:51951699-51997078 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human ACVR1B associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 5 alleles in 5 genetic backgrounds
    6 phenotypes from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for targeted mutations that inactivate the gene arrest at the egg cylinder stage, prior to gastrulation, showing epiblast and extraembryonic ectoderm disorganization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    78
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1101
  • Tissues
    157
  • cDNA Data
    77
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11479 NCBI Gene Model | MGI Sequence Detail 39613 C57BL/6J ±  kb
    transcript NM_007395 RefSeq | MGI Sequence Detail 4437 Not Specified  
    polypeptide Q61271 UniProt | EBI | MGI Sequence Detail 505 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 85
      Genomic 1
      cDNA 77
      Primer pair 6
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-25637, MGI:104309
    References
    more
    • Summaries
      All 118
      Developmental Gene Expression 26
      Diseases 1
      Gene Ontology 17
      Phenotypes 51
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:354205 Saeki K, et al., Acvr1b Loss Increases Formation of Pancreatic Precancerous Lesions From Acinar and Ductal Cells of Origin. Cell Mol Gastroenterol Hepatol. 2024 Aug 5;18(5):101387
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory