About   Help   FAQ
Ogt Gene Detail
Summary
  • Symbol
    Ogt
  • Name
    O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
  • Synonyms
    1110038P24Rik, 4831420N21Rik, OGT, Ogtl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339639
    NCBI Gene: 108155
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:100683666-100727957 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 44.45 cM, cytoband D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    668 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339639
 protein coding gene ChrX:100683617-100727957 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035964
 protein coding gene ChrX:98168928-98218732 (+)
A/J MGP_AJ_G0035949
 protein coding gene ChrX:98156303-98202472 (+)
AKR/J MGP_AKRJ_G0035865
 protein coding gene ChrX:100986403-101037145 (+)
BALB/cJ MGP_BALBcJ_G0035932
 protein coding gene ChrX:96903836-96949831 (+)
C3H/HeJ MGP_C3HHeJ_G0035641
 protein coding gene ChrX:98566291-98615931 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036461
 protein coding gene ChrX:101082273-101130712 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033291
 protein coding gene ChrX:95894984-95938177 (+)
CAST/EiJ MGP_CASTEiJ_G0034928
 protein coding gene ChrX:82873011-82920427 (+)
CBA/J MGP_CBAJ_G0035616
 protein coding gene ChrX:104216471-104269145 (+)
DBA/2J MGP_DBA2J_G0035770
 protein coding gene ChrX:97370338-97414576 (+)
FVB/NJ MGP_FVBNJ_G0035708
 protein coding gene ChrX:96747188-96796591 (+)
LP/J MGP_LPJ_G0035860
 protein coding gene ChrX:99116266-99163715 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035743
 protein coding gene ChrX:108754393-108808246 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036488
 protein coding gene ChrX:97849394-97897102 (+)
PWK/PhJ MGP_PWKPhJ_G0034627
 protein coding gene ChrX:80472887-80517271 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034455
 protein coding gene ChrX:83789315-83839379 (+)
WSB/EiJ MGP_WSBEiJ_G0035067
 protein coding gene ChrX:96558984-96602720 (+)



Homology
more
  • Human Ortholog
    OGT, O-linked N-acetylglucosamine (GlcNAc) transferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OGT, O-linked N-acetylglucosamine (GlcNAc) transferase
  • Synonyms
    HINCUT-1, HRNT1, MRX106, O-GLCNAC, OGT1, XLID106
  • Links
    NCBI Gene ID: 8473
    neXtProt AC: NX_O15294
    UniProt: O15294

  • Chr Location
    Xq13.1; chrX:71533087-71575892 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ogt mouse models; 1 with human OGT associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 3 alleles in 5 genetic backgrounds
    1 images
    72 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Conditional deletion of this gene results in cell death in hemizygous and homozygous cells. Following germline conditional deletion only females inheriting the deletion paternally survive.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    125
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    850
  • Tissues
    104
  • cDNA Data
    22
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034160 Ensembl Gene Model | MGI Sequence Detail 44292 C57BL/6J ±  kb
    transcript ENSMUST00000044475 Ensembl | MGI Sequence Detail 5384 Not Applicable  
    polypeptide ENSMUSP00000045409 Ensembl | MGI Sequence Detail 1046 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 25
      Primer pair 4
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-39587, MGI:109588, MGI:1923575, MGI:1924387, MGI:2147844
    References
    more
    • Summaries
      All 146
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 26
      Phenotypes 72
    • Earliest
      J:39462 Kreppel LK, et al., Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats. J Biol Chem. 1997 Apr 4;272(14):9308-15
    • Latest
      J:358134 Soma S, et al., O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation. Stem Cells. 2024 Jan 13;42(1):55-63
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory