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Myh2 Gene Detail
Summary
  • Symbol
    Myh2
  • Name
    myosin, heavy polypeptide 2, skeletal muscle, adult
  • Synonyms
    MHC2A, MyHC-IIa, Myhs-f, Myhs-f1, Myhsf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339710
    NCBI Gene: 17882
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:67061853-67088343 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 40.59 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    845 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339710
 protein coding gene Chr11:67061853-67088343 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018486
 protein coding gene Chr11:67454008-67486817 (+)
A/J MGP_AJ_G0018455
 protein coding gene Chr11:64928597-64956208 (+)
AKR/J MGP_AKRJ_G0018424
 protein coding gene Chr11:66867779-66897770 (+)
BALB/cJ MGP_BALBcJ_G0018426
 protein coding gene Chr11:65209722-65236260 (+)
C3H/HeJ MGP_C3HHeJ_G0018239
 protein coding gene Chr11:66882792-66886349 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018878
 protein coding gene Chr11:69498164-69525711 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016522
 protein coding gene Chr11:61885797-61912547 (+)
CAST/EiJ MGP_CASTEiJ_G0017795
 protein coding gene Chr11:67100792-67134642 (+)
CBA/J MGP_CBAJ_G0018213
 protein coding gene Chr11:72549560-72553118 (+)
DBA/2J MGP_DBA2J_G0018322
 protein coding gene Chr11:64470982-64474540 (+)
FVB/NJ MGP_FVBNJ_G0018312
 protein coding gene Chr11:64138817-64165642 (+)
LP/J MGP_LPJ_G0018394
 protein coding gene Chr11:68005781-68034982 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018336
 protein coding gene Chr11:73373859-73389091 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018919
 protein coding gene Chr11:67104141-67133014 (+)
PWK/PhJ MGP_PWKPhJ_G0017571
 protein coding gene Chr11:65143340-65173361 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017359
 protein coding gene Chr11:66926460-66956140 (+)
WSB/EiJ MGP_WSBEiJ_G0017848
 protein coding gene Chr11:66723240-66750633 (+)



Homology
more
  • Human Ortholog
    MYH2, myosin heavy chain 2
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYH2, myosin heavy chain 2
  • Synonyms
    CMYO6, CMYP6, IBM3, MYH2A, MYHas8, MyHC-2A, MyHC-IIa, MYHSA2, MYPOP
  • Links
    NCBI Gene ID: 4620
    neXtProt AC: NX_Q9UKX2
    UniProt: Q9UKX2

  • Chr Location
    17p13.1; chr17:10521148-10549700 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human MYH2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    927
  • Tissues
    56
  • cDNA Data
    18
  • Literature Summary
    79
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17882 NCBI Gene Model | MGI Sequence Detail 26491 C57BL/6J ±  kb
transcript NM_001039545 RefSeq | MGI Sequence Detail 6083 Not Specified  
polypeptide G3UW82 UniProt | EBI | MGI Sequence Detail 1942 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR014751 DNA repair protein XRCC4-like, C-terminal
    IPR000048 IQ motif, EF-hand binding site
    IPR036961 Kinesin motor domain superfamily
    IPR001609 Myosin head, motor domain
    IPR004009 Myosin, N-terminal, SH3-like
    IPR008989 Myosin S1 fragment, N-terminal
    IPR002928 Myosin tail
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
  • GlyGen
    G3UW82 2 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 44
    Genomic 12
    cDNA 19
    Primer pair 13

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12755, MGD-MRK-12756, MGD-MRK-12760, MGI:97263
References
more
  • Summaries
    All 152
    Developmental Gene Expression 79
    Gene Ontology 9
    Phenotypes 11
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:347774 Kolonay DW, et al., Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease. Front Cell Dev Biol. 2024;12:1331563
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory