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Cxcl15 Gene Detail
Summary
  • Symbol
    Cxcl15
  • Name
    C-X-C motif chemokine ligand 15
  • Synonyms
    Il8, lungkine, Scyb15, weche
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339941
    NCBI Gene: 20309
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:90942393-90950926 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 44.78 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339941
 protein coding gene Chr5:90942393-90950926 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029730
 protein coding gene Chr5:91892503-91901123 (+)
A/J MGP_AJ_G0029696
 protein coding gene Chr5:88259455-88268128 (+)
AKR/J MGP_AKRJ_G0029642
 protein coding gene Chr5:91121470-91131514 (+)
BALB/cJ MGP_BALBcJ_G0029706
 protein coding gene Chr5:89168324-89177972 (+)
C3H/HeJ MGP_C3HHeJ_G0029429
 protein coding gene Chr5:91542635-91551256 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030160
 protein coding gene Chr5:95559146-95569349 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027396
 protein coding gene Chr5:83963763-83975439 (+)
CAST/EiJ MGP_CASTEiJ_G0028839
 protein coding gene Chr5:90915291-90923650 (+)
CBA/J MGP_CBAJ_G0029399
 protein coding gene Chr5:98829481-98838358 (+)
DBA/2J MGP_DBA2J_G0029543
 protein coding gene Chr5:88341040-88349562 (+)
FVB/NJ MGP_FVBNJ_G0029502
 protein coding gene Chr5:87196059-87204926 (+)
LP/J MGP_LPJ_G0029631
 protein coding gene Chr5:92265637-92275608 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029531
 protein coding gene Chr5:103814830-103826840 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030194
 protein coding gene Chr5:90666779-90676646 (+)
PWK/PhJ MGP_PWKPhJ_G0028558
 protein coding gene Chr5:87393473-87402534 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028393
 protein coding gene Chr5:90082257-90090696 (+)
WSB/EiJ MGP_WSBEiJ_G0028918
 protein coding gene Chr5:91122524-91131437 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    4
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    4 involving Cxcl15
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    16 strains or lines available
Mice homozygous for a targeted null mutation are viable and fertile but display reduced host defense against the pulmonary pathogen Klebsiella pneumoniae.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    795
  • Tissues
    59
  • cDNA Data
    12
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20309 NCBI Gene Model | MGI Sequence Detail 8534 C57BL/6J ±  kb
transcript NM_011339 RefSeq | MGI Sequence Detail 2127 ZRU/MplStud  
polypeptide Q9WVL7 UniProt | EBI | MGI Sequence Detail 167 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 12
    Primer pair 4

    Microarray probesets 4
References
more
  • Summaries
    All 50
    Developmental Gene Expression 10
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory