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Sema4f Gene Detail
Summary
  • Symbol
    Sema4f
  • Name
    sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain
  • Synonyms
    Sema W
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340055
    NCBI Gene: 20355
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:82888865-82916724 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    154 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1340055
 protein coding gene Chr6:82888865-82916750 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030907
 protein coding gene Chr6:83903320-83930771 (-)
A/J MGP_AJ_G0030876
 protein coding gene Chr6:80700629-80728590 (-)
AKR/J MGP_AKRJ_G0030804
 protein coding gene Chr6:83024738-83055865 (-)
BALB/cJ MGP_BALBcJ_G0030886
 protein coding gene Chr6:80714420-80742478 (-)
C3H/HeJ MGP_C3HHeJ_G0030824
 protein coding gene Chr6:101328142-101359748 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031346
 protein coding gene Chr6:86182472-86212841 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028532
 protein coding gene Chr6:79051848-79079199 (-)
CAST/EiJ MGP_CASTEiJ_G0029995
 protein coding gene Chr6:83023175-83054365 (-)
CBA/J MGP_CBAJ_G0030573
 protein coding gene Chr6:89598306-89627999 (-)
DBA/2J MGP_DBA2J_G0030726
 protein coding gene Chr6:80019279-80047899 (-)
FVB/NJ MGP_FVBNJ_G0030679
 protein coding gene Chr6:79227327-79255483 (-)
LP/J MGP_LPJ_G0030805
 protein coding gene Chr6:83895279-83924454 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030715
 protein coding gene Chr6:93901737-93931948 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031370
 protein coding gene Chr6:82842114-82870311 (-)
PWK/PhJ MGP_PWKPhJ_G0029710
 protein coding gene Chr6:78911659-78939523 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029538
 protein coding gene Chr6:81686684-81713845 (-)
WSB/EiJ MGP_WSBEiJ_G0030076
 protein coding gene Chr6:83279041-83307439 (-)



Homology
more
  • Human Ortholog
    SEMA4F, ssemaphorin 4F
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEMA4F, ssemaphorin 4F
  • Synonyms
    M-SEMA, m-Sema-M, PRO2353, S4F, SEMAM, SEMAW
  • Links
    NCBI Gene ID: 10505
    neXtProt AC: NX_O95754
    UniProt: O95754

  • Chr Location
    2p13.1; chr2:74654228-74709713 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    62
  • cDNA Data
    22
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20355 NCBI Gene Model | MGI Sequence Detail 27860 C57BL/6J ±  kb
    transcript NM_011350 RefSeq | MGI Sequence Detail 4060 ZRU/MplStud  
    polypeptide Q9Z123 UniProt | EBI | MGI Sequence Detail 777 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 1
      cDNA 24
      Primer pair 2
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 17
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:53335 Encinas JA, et al., Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2491-6
    • Latest
      J:330969 Martins LF, et al., Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity. Neuron. 2022 Oct 7;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory