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Uba3 Gene Detail
Summary
  • Symbol
    Uba3
  • Name
    ubiquitin-like modifier activating enzyme 3
  • Synonyms
    A830034N06Rik, Ube1c, ubiquitin activating enzyme 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341217
    NCBI Gene: 22200
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:97160631-97182608 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 44.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    576 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341217
 protein coding gene Chr6:97160593-97182608 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031074
 protein coding gene Chr6:99013640-99035631 (-)
A/J MGP_AJ_G0031043
 protein coding gene Chr6:95268839-95291944 (-)
AKR/J MGP_AKRJ_G0030974
 protein coding gene Chr6:97890786-97912743 (-)
BALB/cJ MGP_BALBcJ_G0031054
 protein coding gene Chr6:95227444-95249403 (-)
C3H/HeJ MGP_C3HHeJ_G0030654
 protein coding gene Chr6:86520609-86543087 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031513
 protein coding gene Chr6:101525130-101549664 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028678
 protein coding gene Chr6:93127010-93149152 (-)
CAST/EiJ MGP_CASTEiJ_G0030161
 protein coding gene Chr6:98063629-98085215 (-)
CBA/J MGP_CBAJ_G0030740
 protein coding gene Chr6:105391934-105413943 (-)
DBA/2J MGP_DBA2J_G0030893
 protein coding gene Chr6:94410617-94432713 (-)
FVB/NJ MGP_FVBNJ_G0030847
 protein coding gene Chr6:93589098-93611071 (-)
LP/J MGP_LPJ_G0030973
 protein coding gene Chr6:99041545-99068699 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030881
 protein coding gene Chr6:109308534-109332992 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031540
 protein coding gene Chr6:97760873-97782893 (-)
PWK/PhJ MGP_PWKPhJ_G0029877
 protein coding gene Chr6:93387731-93410141 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029705
 protein coding gene Chr6:96657450-96679504 (-)
WSB/EiJ MGP_WSBEiJ_G0030245
 protein coding gene Chr6:98225299-98249823 (-)



Homology
more
  • Human Ortholog
    UBA3, ubiquitin like modifier activating enzyme 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBA3, ubiquitin like modifier activating enzyme 3
  • Synonyms
    hUBA3, NAE2, UBE1C
  • Links
    NCBI Gene ID: 9039
    neXtProt AC: NX_Q8TBC4
    UniProt: Q8TBC4

  • Chr Location
    3p14.1; chr3:69054730-69080408 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants die at the peri-implantation stage. Mutants exhibit selective apoptosis of the inner cell mass but not of trophoblastic cells. Moreover, the trophoblastic cells fail to enter the S phase of the endoreduplication cycle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    5
  • cDNA Data
    20
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030061 Ensembl Gene Model | MGI Sequence Detail 21978 C57BL/6J ±  kb
    transcript ENSMUST00000089287 Ensembl | MGI Sequence Detail 2257 Not Applicable  
    polypeptide ENSMUSP00000086701 Ensembl | MGI Sequence Detail 462 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000016952 NEDD8-activating enzyme E1 catalytic subunit
      (term hierarchy)
    • EC
      6.2.1.64
    • InterPro Domains
      IPR014929 E2 binding
      IPR030468 NEDD8-activating enzyme E1 catalytic subunit, N-terminal domain
      IPR045886 ThiF/MoeB/HesA family
      IPR000594 THIF-type NAD/FAD binding fold
      IPR035985 Ubiquitin-activating enzyme
      IPR023318 Ubiquitin activating enzyme, alpha domain superfamily
      IPR033127 Ubiquitin-activating enzyme E1, Cys active site
    • GlyGen
      Q8C878 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 21

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1353580, MGI:2141496, MGI:2141693, MGI:2441832
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 17
    • Earliest
      J:54622 Gong L, et al., Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. J Biol Chem. 1999 Apr 23;274(17):12036-42
    • Latest
      J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory