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Trpv1 Gene Detail
Summary
  • Symbol
    Trpv1
  • Name
    transient receptor potential cation channel, subfamily V, member 1
  • Synonyms
    capsaicin receptor, OTRPC1, Vr1, VR-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341787
    NCBI Gene: 193034
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr11:73125118-73152068 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 45.25 cM, cytoband B3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    215 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341787
 protein coding gene Chr11:73124975-73152148 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018658
 protein coding gene Chr11:73916837-73944375 (+)
A/J MGP_AJ_G0018626
 protein coding gene Chr11:71144265-71173401 (+)
AKR/J MGP_AKRJ_G0018595
 protein coding gene Chr11:73316993-73345979 (+)
BALB/cJ MGP_BALBcJ_G0018598
 protein coding gene Chr11:71444437-71472644 (+)
C3H/HeJ MGP_C3HHeJ_G0018411
 protein coding gene Chr11:73267449-73295600 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019049
 protein coding gene Chr11:76166698-76193631 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016692
 protein coding gene Chr11:67942893-67977187 (+)
CAST/EiJ MGP_CASTEiJ_G0017966
 protein coding gene Chr11:73652551-73684770 (+)
CBA/J MGP_CBAJ_G0018383
 protein coding gene Chr11:79513725-79546702 (+)
DBA/2J MGP_DBA2J_G0018492
 protein coding gene Chr11:70769636-70796709 (+)
FVB/NJ MGP_FVBNJ_G0018483
 protein coding gene Chr11:70316029-70344655 (+)
LP/J MGP_LPJ_G0018563
 protein coding gene Chr11:74431706-74459389 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018506
 protein coding gene Chr11:80029633-80062409 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019091
 protein coding gene Chr11:73497491-73525371 (+)
PWK/PhJ MGP_PWKPhJ_G0017739
 protein coding gene Chr11:71412788-71442936 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017529
 protein coding gene Chr11:73214877-73243895 (+)
WSB/EiJ MGP_WSBEiJ_G0018020
 protein coding gene Chr11:73249027-73281049 (+)



Homology
more
  • Human Ortholog
    TRPV1, transient receptor potential cation channel subfamily V member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPV1, transient receptor potential cation channel subfamily V member 1
  • Synonyms
    VR1
  • Links
    NCBI Gene ID: 7442
    neXtProt AC: NX_Q8NER1
    UniProt: Q8NER1

  • Chr Location
    17p13.2; chr17:3565444-3609411 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TRPV1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    62 phenotypes from 2 alleles in 6 genetic backgrounds
    4 phenotypes from multigenic genotypes
    511 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice demonstrate abnormal nociception, abnormal anxiety- and conditioning-related behaviors, increased sensitivity to DOCA-salt-induced renal damage, resistance to diet-induced obesity, altered taste sensitivity, and impaired febrile response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    134
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    981
  • Tissues
    98
  • cDNA Data
    4
  • Literature Summary
    48
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005952 Ensembl Gene Model | MGI Sequence Detail 26951 C57BL/6J ±  kb
    transcript ENSMUST00000102526 Ensembl | MGI Sequence Detail 3361 Not Applicable  
    polypeptide ENSMUSP00000099585 Ensembl | MGI Sequence Detail 839 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000001065 transient receptor potential cation channel TRPV1
      (term hierarchy)
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR005821 Ion transport domain
      IPR024862 Transient receptor potential cation channel subfamily V
      IPR008347 Transient receptor potential cation channel subfamily V member 1-4
    • GlyGen
      Q704Y3 1 site
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 5
      Primer pair 3
      Other 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 698
      Developmental Gene Expression 48
      Gene Ontology 30
      Phenotypes 511
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:359108 Fattori V, et al., Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice. Sci Transl Med. 2024 Nov 6;16(772):eadk8230
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory