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Cnga3 Gene Detail
Summary
  • Symbol
    Cnga3
  • Name
    cyclic nucleotide gated channel alpha 3
  • Synonyms
    CNG3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341818
    NCBI Gene: 12790
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:37257317-37302465 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 15.46 cM, cytoband B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1601 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341818
 protein coding gene Chr1:37253515-37302465 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015935
 protein coding gene Chr1:35819117-35875189 (+)
A/J MGP_AJ_G0015919
 protein coding gene Chr1:34828876-34894857 (+)
AKR/J MGP_AKRJ_G0015874
 protein coding gene Chr1:35328848-35379208 (+)
BALB/cJ MGP_BALBcJ_G0015873
 protein coding gene Chr1:34513348-34566968 (+)
C3H/HeJ MGP_C3HHeJ_G0015706
 protein coding gene Chr1:35533482-35599073 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016326
 protein coding gene Chr1:37406268-37461348 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014048
 protein coding gene Chr1:31864957-31914861 (+)
CAST/EiJ MGP_CASTEiJ_G0015287
 protein coding gene Chr1:35413245-35463188 (+)
CBA/J MGP_CBAJ_G0015678
 protein coding gene Chr1:38412144-38472354 (+)
DBA/2J MGP_DBA2J_G0015779
 protein coding gene Chr1:34160786-34219410 (+)
FVB/NJ MGP_FVBNJ_G0015781
 protein coding gene Chr1:33692152-33742089 (+)
LP/J MGP_LPJ_G0015849
 protein coding gene Chr1:36169029-36223281 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015801
 protein coding gene Chr1:40591756-40673548 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016373
 protein coding gene Chr1:35387409-35440946 (+)
PWK/PhJ MGP_PWKPhJ_G0015070
 protein coding gene Chr1:33923236-33978998 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014852
 protein coding gene Chr1:35321005-35370251 (+)
WSB/EiJ MGP_WSBEiJ_G0015349
 protein coding gene Chr1:35336371-35388522 (+)



Homology
more
  • Human Ortholog
    CNGA3, cyclic nucleotide gated channel subunit alpha 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNGA3, cyclic nucleotide gated channel subunit alpha 3
  • Synonyms
    ACHM2, CCNC1, CCNCa, CCNCalpha, CNCG3, CNG3
  • Links
    NCBI Gene ID: 1261
    neXtProt AC: NX_Q16281
    UniProt: Q16281

  • Chr Location
    2q11.2; chr2:98346188-98398601 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cnga3 mouse models; 2 with human CNGA3 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    1 images
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant animals experience progressive loss of cone photoreceptor cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    7
  • cDNA Data
    2
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12790 NCBI Gene Model | MGI Sequence Detail 45149 C57BL/6J ±  kb
    transcript NM_001282010 RefSeq | MGI Sequence Detail 3609 C57BL/6  
    polypeptide Q9JJZ8 UniProt | EBI | MGI Sequence Detail 631 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000000696 cyclic nucleotide-gated cation channel alpha-3
      (term hierarchy)
    • InterPro Domains
      IPR018488 Cyclic nucleotide-binding, conserved site
      IPR000595 Cyclic nucleotide-binding domain
      IPR018490 Cyclic nucleotide-binding domain superfamily
      IPR050866 Cyclic Nucleotide-Gated Cation Channel
      IPR032406 Cyclic nucleotide-gated channel, C-terminal leucine zipper domain
      IPR005821 Ion transport domain
      IPR014710 RmlC-like jelly roll fold
    • GlyGen
      Q9JJZ8 1 site
    Molecular
    Reagents
    less
    • All nucleic 2
      cDNA 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 101
      Developmental Gene Expression 3
      Diseases 3
      Gene Ontology 10
      Phenotypes 69
    • Earliest
      J:56020 Biel M, et al., Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7553-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory