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Ajuba Gene Detail
Summary
  • Symbol
    Ajuba
  • Name
    ajuba LIM protein
  • Synonyms
    Jub
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341886
    NCBI Gene: 16475
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:54804929-54815015 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 27.84 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    283 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341886
 protein coding gene Chr14:54804926-54815118 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021314
 protein coding gene Chr14:48526720-48538257 (-)
A/J MGP_AJ_G0021273
 protein coding gene Chr14:47579155-47590070 (-)
AKR/J MGP_AKRJ_G0021249
 protein coding gene Chr14:49291855-49301910 (-)
BALB/cJ MGP_BALBcJ_G0021277
 protein coding gene Chr14:47551120-47562051 (-)
C3H/HeJ MGP_C3HHeJ_G0021057
 protein coding gene Chr14:48992609-49002811 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021716
 protein coding gene Chr14:50993501-51004518 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019260
 protein coding gene Chr14:45993773-46004284 (-)
CAST/EiJ MGP_CASTEiJ_G0020576
 protein coding gene Chr14:45232201-45242423 (-)
CBA/J MGP_CBAJ_G0021024
 protein coding gene Chr14:52502532-52512660 (-)
DBA/2J MGP_DBA2J_G0021145
 protein coding gene Chr14:47321073-47331137 (-)
FVB/NJ MGP_FVBNJ_G0021127
 protein coding gene Chr14:46773840-46784093 (-)
LP/J MGP_LPJ_G0021219
 protein coding gene Chr14:49533548-49543772 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021151
 protein coding gene Chr14:51924447-51935922 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021742
 protein coding gene Chr14:48484830-48495965 (-)
PWK/PhJ MGP_PWKPhJ_G0020322
 protein coding gene Chr14:43848610-43859092 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020150
 protein coding gene Chr14:44468021-44478176 (-)
WSB/EiJ MGP_WSBEiJ_G0020629
 protein coding gene Chr14:48778382-48788468 (-)



Homology
more
  • Human Ortholog
    AJUBA, ajuba LIM protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AJUBA, ajuba LIM protein
  • Synonyms
    JUB
  • Links
    NCBI Gene ID: 84962
    neXtProt AC: NX_Q96IF1
    UniProt: Q96IF1

  • Chr Location
    14q11.2; chr14:22971177-22982551 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele are viable and reach adulthood without any obvious phenotypes; however, mouse embryonic fibroblasts exhibit impaired cell migration and abnormal lamellipodia production in vitro. Mice homozygous for a different null allele exhibit complete embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    771
  • Tissues
    60
  • cDNA Data
    31
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022178 Ensembl Gene Model | MGI Sequence Detail 10087 C57BL/6J ±  kb
    transcript ENSMUST00000054487 Ensembl | MGI Sequence Detail 3397 Not Applicable  
    polypeptide ENSMUSP00000056977 Ensembl | MGI Sequence Detail 547 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 32
      Primer pair 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 13
      Gene Ontology 17
      Phenotypes 21
    • Earliest
      J:55014 Goyal RK, et al., Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen- activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner. Mol Cell Biol. 1999 Jun;19(6):4379-89
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory