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Slc23a1 Gene Detail
Summary
  • Symbol
    Slc23a1
  • Name
    solute carrier family 23 (nucleobase transporters), member 1
  • Synonyms
    D18Ucla2, Slc23a2, SVCT1, YSPL3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341903
    NCBI Gene: 20522
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:35747657-35760297 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.17 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    279 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341903
 protein coding gene Chr18:35747657-35762900 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024263
 protein coding gene Chr18:33929557-33942953 (-)
A/J MGP_AJ_G0024229
 protein coding gene Chr18:32753413-32770540 (-)
AKR/J MGP_AKRJ_G0024197
 protein coding gene Chr18:33670829-33688608 (-)
BALB/cJ MGP_BALBcJ_G0024229
 protein coding gene Chr18:32810547-32824364 (-)
C3H/HeJ MGP_C3HHeJ_G0023996
 protein coding gene Chr18:33714051-33726687 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024670
 protein coding gene Chr18:35153971-35166612 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022110
 protein coding gene Chr18:32879404-32892034 (-)
CAST/EiJ MGP_CASTEiJ_G0023471
 protein coding gene Chr18:33704830-33717465 (-)
CBA/J MGP_CBAJ_G0023964
 protein coding gene Chr18:36162563-36179682 (-)
DBA/2J MGP_DBA2J_G0024096
 protein coding gene Chr18:32399089-32412071 (-)
FVB/NJ MGP_FVBNJ_G0024063
 protein coding gene Chr18:32083235-32097329 (-)
LP/J MGP_LPJ_G0024178
 protein coding gene Chr18:33984502-33997134 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024091
 protein coding gene Chr18:37404428-37419459 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024719
 protein coding gene Chr18:33522748-33537368 (-)
PWK/PhJ MGP_PWKPhJ_G0023215
 protein coding gene Chr18:32624393-32637034 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023022
 protein coding gene Chr18:33794249-33810946 (-)
WSB/EiJ MGP_WSBEiJ_G0023534
 protein coding gene Chr18:33448118-33463122 (-)



Homology
more
  • Human Ortholog
    SLC23A1, solute carrier family 23 member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC23A1, solute carrier family 23 member 1
  • Synonyms
    SLC23A2, SVCT1, YSPL3
  • Links
    NCBI Gene ID: 9963
    neXtProt AC: NX_Q9UHI7
    UniProt: Q9UHI7

  • Chr Location
    5q31.2; chr5:139367196-139385676 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal ascorbate homeostasis and early postnatal lethality associated with lethargy and lack of gastric milk. Heterozygous mice of homozgous dams exhibit a similar phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    940
  • Tissues
    203
  • cDNA Data
    38
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024354 Ensembl Gene Model | MGI Sequence Detail 12641 C57BL/6J ±  kb
    transcript ENSMUST00000025212 Ensembl | MGI Sequence Detail 3026 Not Applicable  
    polypeptide ENSMUSP00000025212 Ensembl | MGI Sequence Detail 605 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 38
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-5036, MGI:91192
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 5
    • Earliest
      J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
    • Latest
      J:338261 Toyoda Y, et al., Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations. Pflugers Arch. 2023 Apr;475(4):489-504
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory