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Ly96 Gene Detail
Summary
  • Symbol
    Ly96
  • Name
    lymphocyte antigen 96
  • Synonyms
    ESOP-1, MD-2, MD2, myeloid differentiation factor-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341909
    NCBI Gene: 17087
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:16758680-16779829 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 5.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    765 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341909
 protein coding gene Chr1:16758275-16779835 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015859
 protein coding gene Chr1:14204427-14228362 (+)
A/J MGP_AJ_G0015840
 protein coding gene Chr1:14024186-14045642 (+)
AKR/J MGP_AKRJ_G0015799
 protein coding gene Chr1:14049261-14075681 (+)
BALB/cJ MGP_BALBcJ_G0015796
 protein coding gene Chr1:13756609-13779615 (+)
C3H/HeJ MGP_C3HHeJ_G0015630
 protein coding gene Chr1:14085221-14108990 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016250
 protein coding gene Chr1:14819679-14843528 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0013971
 protein coding gene Chr1:12626384-12647750 (+)
CAST/EiJ MGP_CASTEiJ_G0015211
 protein coding gene Chr1:14159355-14185058 (+)
CBA/J MGP_CBAJ_G0015603
 protein coding gene Chr1:15178430-15199689 (+)
DBA/2J MGP_DBA2J_G0015702
 protein coding gene Chr1:13624862-13646212 (+)
FVB/NJ MGP_FVBNJ_G0015707
 protein coding gene Chr1:13411931-13433232 (+)
LP/J MGP_LPJ_G0015774
 protein coding gene Chr1:14409136-14432628 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015726
 protein coding gene Chr1:15787297-15810739 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016297
 protein coding gene Chr1:14013194-14034752 (+)
PWK/PhJ MGP_PWKPhJ_G0014995
 protein coding gene Chr1:13399618-13421537 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014776
 protein coding gene Chr1:14203587-14225876 (+)
WSB/EiJ MGP_WSBEiJ_G0015274
 protein coding gene Chr1:13942248-13965319 (+)



Homology
more
  • Human Ortholog
    LY96, lymphocyte antigen 96
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LY96, lymphocyte antigen 96
  • Synonyms
    ESOP-1, ly-96, MD-2, MD2
  • Links
    NCBI Gene ID: 23643
    neXtProt AC: NX_Q9Y6Y9
    UniProt: Q9Y6Y9

  • Chr Location
    8q21.11; chr8:73991392-74099857 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display impaired responsiveness to LPS, are resistant to LPS-induced lethal toxicity but show increased susceptibility to Salmonella typhimurium infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    34
  • cDNA Data
    7
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 17087 NCBI Gene Model | MGI Sequence Detail 21150 C57BL/6J ±  kb
transcript NM_016923 RefSeq | MGI Sequence Detail 603 C57BL/6  
polypeptide Q9JHF9 UniProt | EBI | MGI Sequence Detail 160 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 2
References
more
  • Summaries
    All 115
    Developmental Gene Expression 1
    Gene Ontology 13
    Phenotypes 57
  • Earliest
    J:55323 Shimazu R, et al., MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med. 1999 Jun 7;189(11):1777-82
  • Latest
    J:347100 Wang M, et al., Inhibition of MD2 by natural product-drived JM-9 attenuates renal inflammation and diabetic nephropathy in mice. Biomed Pharmacother. 2023 Dec;168:115660
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory