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Unc13b Gene Detail
Summary
  • Symbol
    Unc13b
  • Name
    unc-13 homolog B
  • Synonyms
    Munc13-2, Unc13h2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342278
    NCBI Gene: 22249
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:43058953-43264871 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 23.00 cM, cytoband B1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    5250 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342278
 protein coding gene Chr4:43046193-43264873 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028201
 protein coding gene Chr4:41141722-41362888 (+)
A/J MGP_AJ_G0028157
 protein coding gene Chr4:39699319-39903316 (+)
AKR/J MGP_AKRJ_G0028109
 protein coding gene Chr4:40606454-40811612 (+)
BALB/cJ MGP_BALBcJ_G0028177
 protein coding gene Chr4:39792010-39994240 (+)
C3H/HeJ MGP_C3HHeJ_G0027899
 protein coding gene Chr4:41230005-41431203 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028618
 protein coding gene Chr4:42676497-42891060 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025930
 protein coding gene Chr4:37164526-37353736 (+)
CAST/EiJ MGP_CASTEiJ_G0027339
 protein coding gene Chr4:40706932-40932554 (+)
CBA/J MGP_CBAJ_G0027865
 protein coding gene Chr4:44017571-44226810 (+)
DBA/2J MGP_DBA2J_G0028014
 protein coding gene Chr4:39614509-39817657 (+)
FVB/NJ MGP_FVBNJ_G0027981
 protein coding gene Chr4:38837205-39034816 (+)
LP/J MGP_LPJ_G0028113
 protein coding gene Chr4:41208490-41420075 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028005
 protein coding gene Chr4:47287848-47500034 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028654
 protein coding gene Chr4:40799134-41004163 (+)
PWK/PhJ MGP_PWKPhJ_G0027065
 protein coding gene Chr4:39649147-39849572 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026891
 protein coding gene Chr4:40351567-40562910 (+)
WSB/EiJ MGP_WSBEiJ_G0027419
 protein coding gene Chr4:40704926-40907580 (+)



Homology
more
  • Human Ortholog
    UNC13B, unc-13 homolog B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UNC13B, unc-13 homolog B
  • Synonyms
    MUNC13, munc13-2, UNC13, Unc13h2
  • Links
    NCBI Gene ID: 10497
    neXtProt AC: NX_O14795
    UniProt: O14795

  • Chr Location
    9p13.3; chr9:35161992-35405338 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are grossly phenotypically normal. Mice older than 12 months will exhibit sporadic seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    75
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    61
  • cDNA Data
    92
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028456 Ensembl Gene Model | MGI Sequence Detail 205919 C57BL/6J ±  kb
    transcript ENSMUST00000207569 Ensembl | MGI Sequence Detail 14754 Not Applicable  
    polypeptide ENSMUSP00000147100 Ensembl | MGI Sequence Detail 4390 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 94
      Genomic 1
      cDNA 93

      Microarray probesets 3
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 5
      Gene Ontology 18
      Phenotypes 47
    • Earliest
      J:56513 Augustin I, et al., Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles. Nature. 1999 Jul 29;400(6743):457-61
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory