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Ikzf4 Gene Detail
Summary
  • Symbol
    Ikzf4
  • Name
    IKAROS family zinc finger 4
  • Synonyms
    A630026H08Rik, Eos, Zfpn1a4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343139
    NCBI Gene: 22781
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128466712-128505227 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 77.11 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    825 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343139
 protein coding gene Chr10:128466708-128505668 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017875
 protein coding gene Chr10:132391084-132406152 (-)
A/J MGP_AJ_G0017850
 protein coding gene Chr10:127079082-127094173 (-)
AKR/J MGP_AKRJ_G0017813
 protein coding gene Chr10:130795122-130810035 (-)
BALB/cJ MGP_BALBcJ_G0017814
 protein coding gene Chr10:127445873-127461309 (-)
C3H/HeJ MGP_C3HHeJ_G0017637
 protein coding gene Chr10:130960979-130976101 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018269
 protein coding gene Chr10:136868477-136883530 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015947
 protein coding gene Chr10:120994927-121010071 (-)
CAST/EiJ MGP_CASTEiJ_G0017198
 protein coding gene Chr10:131681671-131698599 (-)
CBA/J MGP_CBAJ_G0017607
 protein coding gene Chr10:142447264-142462367 (-)
DBA/2J MGP_DBA2J_G0017713
 protein coding gene Chr10:126140451-126155538 (-)
FVB/NJ MGP_FVBNJ_G0017708
 protein coding gene Chr10:125053711-125070002 (-)
LP/J MGP_LPJ_G0017787
 protein coding gene Chr10:132987542-133003128 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017736
 protein coding gene Chr10:145019766-145035821 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018309
 protein coding gene Chr10:130896517-130911641 (-)
PWK/PhJ MGP_PWKPhJ_G0016983
 protein coding gene Chr10:126393818-126410042 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016772
 protein coding gene Chr10:130011525-130026976 (-)
WSB/EiJ MGP_WSBEiJ_G0017257
 protein coding gene Chr10:131116969-131133148 (-)



Homology
more
  • Human Ortholog
    IKZF4, IKAROS family zinc finger 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IKZF4, IKAROS family zinc finger 4
  • Synonyms
    EOS, ZNFN1A4
  • Links
    NCBI Gene ID: 64375
    neXtProt AC: NX_Q9H2S9
    UniProt: Q9H2S9

  • Chr Location
    12q13.2; chr12:56007504-56038435 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ikzf4 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 3 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout reduces proliferation rate of conventional T cells and causes increased susceptibility to experimental autoimmune encephalomyelitis. Conditional knockout in regulatory T cells (Tregs) results in enlarged spleen and lymph nodes and chronic inflammation of internal organs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    815
  • Tissues
    102
  • cDNA Data
    28
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002578 Ensembl Gene Model | MGI Sequence Detail 38516 C57BL/6J ±  kb
    transcript ENSMUST00000221150 Ensembl | MGI Sequence Detail 2213 Not Applicable  
    polypeptide ENSMUSP00000152617 Ensembl | MGI Sequence Detail 686 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 29
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2441811
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:53896 Honma Y, et al., Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system. FEBS Lett. 1999 Mar 19;447(1):76-80
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory