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Katna1 Gene Detail
Summary
  • Symbol
    Katna1
  • Name
    katanin p60 (ATPase-containing) subunit A1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344353
    NCBI Gene: 23924
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:7601764-7638914 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 2.32 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1093 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344353
 protein coding gene Chr10:7601748-7638914 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016998
 protein coding gene Chr10:4951062-4989003 (+)
A/J MGP_AJ_G0016976
 protein coding gene Chr10:4703670-4741508 (+)
AKR/J MGP_AKRJ_G0016940
 protein coding gene Chr10:4795820-4835165 (+)
BALB/cJ MGP_BALBcJ_G0016934
 protein coding gene Chr10:4677249-4713954 (+)
C3H/HeJ MGP_C3HHeJ_G0016759
 protein coding gene Chr10:4929295-4967238 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017396
 protein coding gene Chr10:5060251-5104469 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015101
 protein coding gene Chr10:4296932-4334887 (+)
CAST/EiJ MGP_CASTEiJ_G0016341
 protein coding gene Chr10:4834867-4884639 (+)
CBA/J MGP_CBAJ_G0016731
 protein coding gene Chr10:5214464-5257931 (+)
DBA/2J MGP_DBA2J_G0016839
 protein coding gene Chr10:4634166-4670417 (+)
FVB/NJ MGP_FVBNJ_G0016834
 protein coding gene Chr10:4581876-4617989 (+)
LP/J MGP_LPJ_G0016914
 protein coding gene Chr10:4793585-4832390 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016864
 protein coding gene Chr10:5176993-5214425 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017434
 protein coding gene Chr10:4750092-4788883 (+)
PWK/PhJ MGP_PWKPhJ_G0016126
 protein coding gene Chr10:4606779-4643722 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015908
 protein coding gene Chr10:4828401-4862946 (+)
WSB/EiJ MGP_WSBEiJ_G0016403
 protein coding gene Chr10:4751806-4790030 (+)



Homology
more
  • Human Ortholog
    KATNA1, katanin catalytic subunit A1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KATNA1, katanin catalytic subunit A1
  • Links
    NCBI Gene ID: 11104
    neXtProt AC: NX_O75449
    UniProt: O75449

  • Chr Location
    6q25.1; chr6:149594873-149648990 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit complete prenatal lethality. Heterozygous null mice exhibit altered neuronal progenitor proliferation in the developing cortex and during adult hippocampal neurogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    15
  • cDNA Data
    9
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019794 Ensembl Gene Model | MGI Sequence Detail 37151 C57BL/6J ±  kb
    transcript ENSMUST00000165806 Ensembl | MGI Sequence Detail 1775 Not Applicable  
    polypeptide ENSMUSP00000132514 Ensembl | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 7
      Gene Ontology 13
      Phenotypes 12
    • Earliest
      J:56613 Syu LJ, et al., Lipotransin: a novel docking protein for hormone-sensitive lipase. Mol Cell. 1999 Jul;4(1):109-15
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory