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Tnfsf13b Gene Detail
Summary
  • Symbol
    Tnfsf13b
  • Name
    tumor necrosis factor (ligand) superfamily, member 13b
  • Synonyms
    BAFF, BLyS, D8Ertd387e, TALL-1, zTNF4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344376
    NCBI Gene: 24099
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:10056637-10086000 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 4.55 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    855 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344376
 protein coding gene Chr8:10056467-10089072 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033348
 protein coding gene Chr8:7146995-7178094 (+)
A/J MGP_AJ_G0033328
 protein coding gene Chr8:6900384-6929762 (+)
AKR/J MGP_AKRJ_G0033259
 protein coding gene Chr8:7116312-7144851 (+)
BALB/cJ MGP_BALBcJ_G0033329
 protein coding gene Chr8:7041421-7069912 (+)
C3H/HeJ MGP_C3HHeJ_G0033042
 protein coding gene Chr8:7276952-7306625 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033841
 protein coding gene Chr8:7452666-7484522 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030811
 protein coding gene Chr8:6447978-6476996 (+)
CAST/EiJ MGP_CASTEiJ_G0032364
 protein coding gene Chr8:6954405-6985514 (+)
CBA/J MGP_CBAJ_G0033015
 protein coding gene Chr8:7758186-7791384 (+)
DBA/2J MGP_DBA2J_G0033168
 protein coding gene Chr8:6899950-6929886 (+)
FVB/NJ MGP_FVBNJ_G0033117
 protein coding gene Chr8:6849331-6878249 (+)
LP/J MGP_LPJ_G0033262
 protein coding gene Chr8:7062108-7093171 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033151
 protein coding gene Chr8:8120411-8163923 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033858
 protein coding gene Chr8:7114166-7144349 (+)
PWK/PhJ MGP_PWKPhJ_G0032077
 protein coding gene Chr8:6856442-6885650 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031919
 protein coding gene Chr8:7022724-7057934 (+)
WSB/EiJ MGP_WSBEiJ_G0032480
 protein coding gene Chr8:7160008-7190562 (+)



Homology
more
  • Human Ortholog
    TNFSF13B, TNF superfamily member 13b
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFSF13B, TNF superfamily member 13b
  • Synonyms
    BAFF, BLYS, CD257, DTL, TALL-1, TALL1, THANK, TNFSF20, TNLG7A, ZTNF4
  • Links
    NCBI Gene ID: 10673
    neXtProt AC: NX_Q9Y275
    UniProt: Q9Y275

  • Chr Location
    13q33.3; chr13:108251240-108308484 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Tnfsf13b mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    79 phenotypes from 7 alleles in 11 genetic backgrounds
    37 phenotypes from multigenic genotypes
    89 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have reduced number of B cells and reduced levels of immunoglobulins.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    18
  • cDNA Data
    15
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 24099 NCBI Gene Model | MGI Sequence Detail 29364 C57BL/6J ±  kb
    transcript NR_189032 RefSeq | MGI Sequence Detail 1753 C57BL/6  
    polypeptide Q9WU72 UniProt | EBI | MGI Sequence Detail 309 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 15
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1196237
    References
    more
    • Summaries
      All 182
      Developmental Gene Expression 2
      Diseases 3
      Gene Ontology 12
      Phenotypes 89
    • Earliest
      J:55624 Schneider P, et al., BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med. 1999 Jun 7;189(11):1747-56
    • Latest
      J:348944 Mockel T, et al., Transcriptome Analysis of BAFF/BAFF-R System in Murine Nephrotoxic Serum Nephritis. Int J Mol Sci. 2024 May 16;25(10)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory