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Dnajb6 Gene Detail
Summary
  • Symbol
    Dnajb6
  • Name
    DnaJ heat shock protein family (Hsp40) member B6
  • Synonyms
    mDj4, Mrj
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344381
    NCBI Gene: 23950
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:29940896-29991476 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 15.27 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1246 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344381
 protein coding gene Chr5:29940686-30023132 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029379
 protein coding gene Chr5:27684190-27783385 (+)
A/J MGP_AJ_G0029345
 protein coding gene Chr5:26758535-26845601 (+)
AKR/J MGP_AKRJ_G0029296
 protein coding gene Chr5:27838457-27932217 (+)
BALB/cJ MGP_BALBcJ_G0029356
 protein coding gene Chr5:27288446-27375107 (+)
C3H/HeJ MGP_C3HHeJ_G0029077
 protein coding gene Chr5:27861610-27952465 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029809
 protein coding gene Chr5:29349334-29449422 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027047
 protein coding gene Chr5:24313541-24391936 (+)
CAST/EiJ MGP_CASTEiJ_G0028488
 protein coding gene Chr5:26969748-27063793 (+)
CBA/J MGP_CBAJ_G0029045
 protein coding gene Chr5:29903948-30010978 (+)
DBA/2J MGP_DBA2J_G0029194
 protein coding gene Chr5:26954632-27046648 (+)
FVB/NJ MGP_FVBNJ_G0029152
 protein coding gene Chr5:26364463-26452566 (+)
LP/J MGP_LPJ_G0029279
 protein coding gene Chr5:28119889-28206663 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029181
 protein coding gene Chr5:30881623-30978344 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029843
 protein coding gene Chr5:27418699-27511525 (+)
PWK/PhJ MGP_PWKPhJ_G0028212
 protein coding gene Chr5:26071750-26157861 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028043
 protein coding gene Chr5:26720262-26814351 (+)
WSB/EiJ MGP_WSBEiJ_G0028568
 protein coding gene Chr5:27469430-27556317 (+)



Homology
more
  • Human Ortholog
    DNAJB6, DnaJ heat shock protein family (Hsp40) member B6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAJB6, DnaJ heat shock protein family (Hsp40) member B6
  • Synonyms
    DJ4, DnaJ, HHDJ1, HSJ-2, HSJ2, LGMD1D, LGMD1E, LGMDD1, MRJ, MSJ-1
  • Links
    NCBI Gene ID: 10049
    neXtProt AC: NX_O75190
    UniProt: O75190

  • Chr Location
    7q36.3; chr7:157335381-157417439 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DNAJB6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants died at mid-gestation due to a failure of chorioallantoic fusion at embryonic day 8.5, and thus preventing the formation of a mature placenta.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    849
  • Tissues
    49
  • cDNA Data
    219
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23950 NCBI Gene Model | MGI Sequence Detail 50581 C57BL/6J ±  kb
    transcript NM_001037940 RefSeq | MGI Sequence Detail 2708 C57BL/6  
    polypeptide O54946 UniProt | EBI | MGI Sequence Detail 365 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 220
      Genomic 1
      cDNA 219

      Microarray probesets 12
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 12
      Phenotypes 40
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:331268 Ding Y, et al., A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. Elife. 2022 Oct 18;11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory