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Spry4 Gene Detail
Summary
  • Symbol
    Spry4
  • Name
    sprouty RTK signaling antagonist 4
  • Synonyms
    A030006O18Rik, sprouty4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345144
    NCBI Gene: 24066
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:38719300-38734400 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 20.50 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    365 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345144
 protein coding gene Chr18:38719300-38734468 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024365
 protein coding gene Chr18:37061712-37076702 (-)
A/J MGP_AJ_G0024332
 protein coding gene Chr18:35774770-35789759 (-)
AKR/J MGP_AKRJ_G0024301
 protein coding gene Chr18:36743823-36758812 (-)
BALB/cJ MGP_BALBcJ_G0024332
 protein coding gene Chr18:35839387-35854376 (-)
C3H/HeJ MGP_C3HHeJ_G0024098
 protein coding gene Chr18:36826425-36841430 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024774
 protein coding gene Chr18:38380611-38395604 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022213
 protein coding gene Chr18:35777434-35792198 (-)
CAST/EiJ MGP_CASTEiJ_G0023573
 protein coding gene Chr18:36782533-36797588 (-)
CBA/J MGP_CBAJ_G0024068
 protein coding gene Chr18:39517149-39532138 (-)
DBA/2J MGP_DBA2J_G0024198
 protein coding gene Chr18:35367484-35382473 (-)
FVB/NJ MGP_FVBNJ_G0024164
 protein coding gene Chr18:35084084-35099084 (-)
LP/J MGP_LPJ_G0024282
 protein coding gene Chr18:37107053-37122054 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024195
 protein coding gene Chr18:40743306-40758297 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024823
 protein coding gene Chr18:36627461-36642458 (-)
PWK/PhJ MGP_PWKPhJ_G0023317
 protein coding gene Chr18:35597922-35613011 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023122
 protein coding gene Chr18:36837729-36852802 (-)
WSB/EiJ MGP_WSBEiJ_G0023636
 protein coding gene Chr18:36524833-36539763 (-)



Homology
more
  • Human Ortholog
    SPRY4, sprouty RTK signaling antagonist 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPRY4, sprouty RTK signaling antagonist 4
  • Synonyms
    HH17
  • Links
    NCBI Gene ID: 81848
    neXtProt AC: NX_Q9C004
    UniProt: Q9C004

  • Chr Location
    5q31.3; chr5:142310427-142326455 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SPRY4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 4 alleles in 4 genetic backgrounds
    20 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for two alleles of this locus display in limb deformation. Mice homozygous for a different allele display partial penetrance of diastema tooth formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1298
  • Tissues
    229
  • cDNA Data
    35
  • Literature Summary
    87
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 24066 NCBI Gene Model | MGI Sequence Detail 15101 C57BL/6J ±  kb
    transcript NM_011898 RefSeq | MGI Sequence Detail 4687 ZRU/MplStud  
    polypeptide Q9WTP2 UniProt | EBI | MGI Sequence Detail 300 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 35
      Primer pair 10
      Other 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2444550
    References
    more
    • Summaries
      All 159
      Developmental Gene Expression 87
      Diseases 2
      Gene Ontology 9
      Phenotypes 41
    • Earliest
      J:54185 de Maximy AA, et al., Cloning and expression pattern of a mouse homologue of drosophila sprouty in the mouse embryo. Mech Dev. 1999 Mar;81(1-2):213-6
    • Latest
      J:353452 Altes G, et al., Multiple endocrine defects in adult-onset Sprouty1/2/4 triple knockout mice. Sci Rep. 2024 Aug 22;14(1):19479
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory