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Cdc6 Gene Detail
Summary
  • Symbol
    Cdc6
  • Name
    cell division cycle 6
  • Synonyms
    CDC18L, CDC18(S.pombe), cell division cycle 18 homolog (S.pombe)-like
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345150
    NCBI Gene: 23834
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98798627-98814766 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 62.74 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    573 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345150
 protein coding gene Chr11:98798627-98814768 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019077
 protein coding gene Chr11:101531840-101551415 (+)
A/J MGP_AJ_G0019045
 protein coding gene Chr11:97266715-97282854 (+)
AKR/J MGP_AKRJ_G0019015
 protein coding gene Chr11:100281977-100299483 (+)
BALB/cJ MGP_BALBcJ_G0019019
 protein coding gene Chr11:97761557-97777607 (+)
C3H/HeJ MGP_C3HHeJ_G0018832
 protein coding gene Chr11:100425992-100442906 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019470
 protein coding gene Chr11:104635735-104656146 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017102
 protein coding gene Chr11:94825006-94840922 (+)
CAST/EiJ MGP_CASTEiJ_G0018386
 protein coding gene Chr11:101411183-101427266 (+)
CBA/J MGP_CBAJ_G0018803
 protein coding gene Chr11:109005190-109024743 (+)
DBA/2J MGP_DBA2J_G0018911
 protein coding gene Chr11:96828967-96845577 (+)
FVB/NJ MGP_FVBNJ_G0018900
 protein coding gene Chr11:96341262-96360029 (+)
LP/J MGP_LPJ_G0018981
 protein coding gene Chr11:101985115-102002388 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018927
 protein coding gene Chr11:108687291-108708452 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019510
 protein coding gene Chr11:100637262-100656953 (+)
PWK/PhJ MGP_PWKPhJ_G0018157
 protein coding gene Chr11:97872516-97889141 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017946
 protein coding gene Chr11:100385024-100406098 (+)
WSB/EiJ MGP_WSBEiJ_G0018435
 protein coding gene Chr11:100595930-100613571 (+)



Homology
more
  • Human Ortholog
    CDC6, cell division cycle 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDC6, cell division cycle 6
  • Synonyms
    CDC18L, HsCDC18, HsCDC6, MGORS5
  • Links
    NCBI Gene ID: 990
    neXtProt AC: NX_Q99741
    UniProt: Q99741

  • Chr Location
    17q21.2; chr17:40287879-40304657 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CDC6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    766
  • Tissues
    32
  • cDNA Data
    89
  • Literature Summary
    13
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000017499 Ensembl Gene Model | MGI Sequence Detail 16140 C57BL/6J ±  kb
transcript ENSMUST00000093937 Ensembl | MGI Sequence Detail 2559 Not Applicable  
polypeptide ENSMUSP00000091469 Ensembl | MGI Sequence Detail 589 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 93
    Genomic 1
    cDNA 89
    Primer pair 3

    Microarray probesets 3
References
more
  • Summaries
    All 60
    Developmental Gene Expression 13
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:54767 Hateboer G, et al., Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F. Mol Cell Biol. 1998 Nov;18(11):6679-97
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory