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Pacsin2 Gene Detail
Summary
  • Symbol
    Pacsin2
  • Name
    protein kinase C and casein kinase substrate in neurons 2
  • Synonyms
    Syndapin II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345153
    NCBI Gene: 23970
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:83259812-83348800 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 39.40 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1668 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345153
 protein coding gene Chr15:83259808-83348807 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022163
 protein coding gene Chr15:84073121-84169767 (-)
A/J MGP_AJ_G0022122
 protein coding gene Chr15:80996562-81089364 (-)
AKR/J MGP_AKRJ_G0022097
 protein coding gene Chr15:83352693-83448000 (-)
BALB/cJ MGP_BALBcJ_G0022128
 protein coding gene Chr15:81137963-81230480 (-)
C3H/HeJ MGP_C3HHeJ_G0021898
 protein coding gene Chr15:83313354-83404642 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022573
 protein coding gene Chr15:87316629-87419037 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020098
 protein coding gene Chr15:77372373-77462740 (-)
CAST/EiJ MGP_CASTEiJ_G0021420
 protein coding gene Chr15:84081585-84175264 (-)
CBA/J MGP_CBAJ_G0021865
 protein coding gene Chr15:90075039-90180163 (-)
DBA/2J MGP_DBA2J_G0021992
 protein coding gene Chr15:80481289-80553638 (-)
FVB/NJ MGP_FVBNJ_G0021971
 protein coding gene Chr15:79523546-79616193 (-)
LP/J MGP_LPJ_G0022063
 protein coding gene Chr15:84247014-84340869 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021991
 protein coding gene Chr15:94988791-95083152 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022588
 protein coding gene Chr15:83356167-83447950 (-)
PWK/PhJ MGP_PWKPhJ_G0021161
 protein coding gene Chr15:80467490-80556314 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020995
 protein coding gene Chr15:83076777-83172805 (-)
WSB/EiJ MGP_WSBEiJ_G0021469
 protein coding gene Chr15:83856171-83949504 (-)



Homology
more
  • Human Ortholog
    PACSIN2, protein kinase C and casein kinase substrate in neurons 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PACSIN2, protein kinase C and casein kinase substrate in neurons 2
  • Synonyms
    SDPII
  • Links
    NCBI Gene ID: 11252
    neXtProt AC: NX_Q9UNF0
    UniProt: Q9UNF0

  • Chr Location
    22q13.2; chr22:42835412-43015149 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced running endurance, distance, and speed with impaired fetal cardiomyocyte electrophysiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    39
  • cDNA Data
    95
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23970 NCBI Gene Model | MGI Sequence Detail 88989 C57BL/6J ±  kb
    transcript NM_001411851 RefSeq | MGI Sequence Detail 3765 C57BL/6  
    polypeptide Q9WVE8 UniProt | EBI | MGI Sequence Detail 486 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 95
      cDNA 95

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145958
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 13
      Phenotypes 35
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory