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Spry3 Gene Detail
Summary
  • Symbol
    Spry3
  • Name
    sprouty RTK signaling antagonist 3
  • Synonyms
    LOC236576, sprouty3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345188
    NCBI Gene: 236576
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • This gene is annotated to Unlocalized Scaffold from chromosome X, MMCHRX_RANDOM_CTG2 (GL456233.2, NT_165789.3) of Assembly GRCm39. UCSC coordinates are chrX_GL456233_random:101352-110912 bp, - strand.
  • Genetic Map
    Chromosome X, Syntenic
Homology
more
  • Human Ortholog
    SPRY3, sprouty RTK signaling antagonist 3
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPRY3, sprouty RTK signaling antagonist 3
  • Synonyms
    spry-3
  • Links
    NCBI Gene ID: 10251
    neXtProt AC: NX_O43610
    UniProt: O43610

  • Chr Location
    XYq28 and Yq12
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    13
  • Tissues
    10
  • cDNA Data
    10
  • Literature Summary
    7
Sequences &
Gene Models
less
  • All Sequences
    15
  • RefSeq
    9
  • UniProt
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic GL456233 GenBank | ENA | DDBJ | MGI Sequence Detail 559103 C57BL/6J ±  kb
transcript NM_001401851 RefSeq | MGI Sequence Detail 4805 ZRU/MplStud  
polypeptide Q3UUD2 UniProt | EBI | MGI Sequence Detail 288 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 10
    Primer pair 1
    Other 1

    Microarray probesets 1
Other
Accession IDs
less
MGI:2685237
References
more
  • Summaries
    All 33
    Developmental Gene Expression 7
    Gene Ontology 9
    Phenotypes 1
  • Earliest
    J:55241 Minowada G, et al., Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed. Development. 1999 Oct;126(20):4465-75
  • Latest
    J:347414 Yang J, et al., A BMP-controlled metabolic/epigenetic signaling cascade directs midfacial morphogenesis. J Clin Invest. 2024 Mar 11;134(8)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory