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Nlrp5 Gene Detail
Summary
  • Symbol
    Nlrp5
  • Name
    NLR family, pyrin domain containing 5
  • Synonyms
    Mater, Nalp5, Op1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345193
    NCBI Gene: 23968
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:23085314-23141347 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 10.22 cM, cytoband A2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1817 from dbSNP Build 142
  • Strain Annotations
    11
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345193
 protein coding gene Chr7:23085314-23141348 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0031783
 protein coding gene Chr7:21069736-21133634 (+)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0031788
 protein coding gene Chr7:21275860-21348619 (+)
C3H/HeJ MGP_C3HHeJ_G0031510
 protein coding gene Chr7:21897191-21961459 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032253
 protein coding gene Chr7:22273424-22351804 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029319
 protein coding gene Chr7:22665560-22707919 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0031472
 protein coding gene Chr7:23049434-23109553 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0031579
 protein coding gene Chr7:20980299-21036194 (+)
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0032282
 protein coding gene Chr7:21273522-21352189 (+)
PWK/PhJ MGP_PWKPhJ_G0030575
 protein coding gene Chr7:15760239-15819001 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0030953
 protein coding gene Chr7:21462787-21528234 (+)



Homology
more
  • Human Ortholog
    NLRP5, NLR family pyrin domain containing 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLRP5, NLR family pyrin domain containing 5
  • Synonyms
    CLR19.8, MATER, NALP5, OZEMA19, PAN11, PYPAF8
  • Links
    NCBI Gene ID: 126206
    neXtProt AC: NX_P59047
    UniProt: P59047

  • Chr Location
    19q13.43; chr19:55999726-56061810 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Females lacking this maternal effect gene are sterile. Preimplantation embryos do not develop past the 2-cell stage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    845
  • Tissues
    42
  • cDNA Data
    51
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015721 Ensembl Gene Model | MGI Sequence Detail 56034 C57BL/6J ±  kb
    transcript ENSMUST00000015866 Ensembl | MGI Sequence Detail 3508 Not Applicable  
    polypeptide ENSMUSP00000015866 Ensembl | MGI Sequence Detail 1111 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      cDNA 53
      Primer pair 6

      Microarray probesets 2
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 24
      Gene Ontology 19
      Phenotypes 13
    • Earliest
      J:56809 Tong ZB, et al., A mouse gene encoding an oocyte antigen associated with autoimmune premature ovarian failure [see comments]. Endocrinology. 1999 Aug;140(8):3720-6
    • Latest
      J:355487 Han Z, et al., The subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3. Nat Commun. 2024 Oct 15;15(1):8887
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory