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Gdf15 Gene Detail
Summary
  • Symbol
    Gdf15
  • Name
    growth differentiation factor 15
  • Synonyms
    macrophage inhibiting cytokine-1, MIC-1, NAG-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346047
    NCBI Gene: 23886
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71082043-71085106 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.15 cM, cytoband C1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    178 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346047
 protein coding gene Chr8:71082043-71085106 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033716
 protein coding gene Chr8:70908459-70911523 (-)
A/J MGP_AJ_G0033699
 protein coding gene Chr8:68029144-68032207 (-)
AKR/J MGP_AKRJ_G0033624
 protein coding gene Chr8:69964504-69967568 (-)
BALB/cJ MGP_BALBcJ_G0033695
 protein coding gene Chr8:68266294-68269358 (-)
C3H/HeJ MGP_C3HHeJ_G0033405
 protein coding gene Chr8:70613377-70616441 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034212
 protein coding gene Chr8:73587830-73590893 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031156
 protein coding gene Chr8:62846848-62849887 (-)
CAST/EiJ MGP_CASTEiJ_G0032730
 protein coding gene Chr8:70102914-70105982 (-)
CBA/J MGP_CBAJ_G0033383
 protein coding gene Chr8:76232408-76235472 (-)
DBA/2J MGP_DBA2J_G0033537
 protein coding gene Chr8:67744090-67747154 (-)
FVB/NJ MGP_FVBNJ_G0033478
 protein coding gene Chr8:66872423-66875487 (-)
LP/J MGP_LPJ_G0033624
 protein coding gene Chr8:70937344-70940408 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033521
 protein coding gene Chr8:78889034-78892097 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034230
 protein coding gene Chr8:70151463-70154527 (-)
PWK/PhJ MGP_PWKPhJ_G0032438
 protein coding gene Chr8:67046386-67049446 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032274
 protein coding gene Chr8:69114907-69117964 (-)
WSB/EiJ MGP_WSBEiJ_G0032845
 protein coding gene Chr8:70511396-70514460 (-)



Homology
more
  • Human Ortholog
    GDF15, growth differentiation factor 15
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GDF15, growth differentiation factor 15
  • Synonyms
    GDF-15, HG, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB
  • Links
    NCBI Gene ID: 9518
    neXtProt AC: NX_Q99988
    UniProt: Q99988

  • Chr Location
    19p13.11; chr19:18374731-18389176 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    82 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice showed no obvious major abnormalities, but exhibit progressive postnatal losses of spinal, facial, and trigeminal motoneurons, accelerated thrombus formation following injury, and decreased bleeding times.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    739
  • Tissues
    30
  • cDNA Data
    10
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23886 NCBI Gene Model | MGI Sequence Detail 3064 C57BL/6J ±  kb
    transcript NM_001330687 RefSeq | MGI Sequence Detail 1381 C57BL/6  
    polypeptide Q9Z0J7 UniProt | EBI | MGI Sequence Detail 303 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 1
      cDNA 10
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 157
      Developmental Gene Expression 12
      Gene Ontology 21
      Phenotypes 82
    • Earliest
      J:57452 Bottner M, et al., Characterization of the rat, mouse, and human genes of growth/differentiation factor-15/ macrophage inhibiting cytokine-1 (GDF-15/MIC-1). Gene. 1999 Sep 3;237(1):105-11
    • Latest
      J:358121 Igual-Gil C, et al., GDF15 is required for maintaining subcutaneous adipose tissue lipid metabolic signature. Sci Rep. 2024 Nov 6;14(1):26989
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory