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Map2k5 Gene Detail
Summary
  • Symbol
    Map2k5
  • Name
    mitogen-activated protein kinase kinase 5
  • Synonyms
    MEK5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346345
    NCBI Gene: 23938
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:63071050-63285184 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 33.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4566 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346345
 protein coding gene Chr9:63071050-63288964 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034928
 protein coding gene Chr9:62753986-62971044 (-)
A/J MGP_AJ_G0034908
 protein coding gene Chr9:60668284-60885094 (-)
AKR/J MGP_AKRJ_G0034838
 protein coding gene Chr9:62083159-62301141 (-)
BALB/cJ MGP_BALBcJ_G0034901
 protein coding gene Chr9:60397948-60612132 (-)
C3H/HeJ MGP_C3HHeJ_G0034611
 protein coding gene Chr9:62596351-62814608 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035420
 protein coding gene Chr9:64484599-64703424 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032331
 protein coding gene Chr9:60323412-60542493 (-)
CAST/EiJ MGP_CASTEiJ_G0033932
 protein coding gene Chr9:62745987-62962318 (-)
CBA/J MGP_CBAJ_G0034582
 protein coding gene Chr9:66699533-66928310 (-)
DBA/2J MGP_DBA2J_G0034741
 protein coding gene Chr9:60458379-60673398 (-)
FVB/NJ MGP_FVBNJ_G0034683
 protein coding gene Chr9:59755772-59970636 (-)
LP/J MGP_LPJ_G0034824
 protein coding gene Chr9:63034944-63255863 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034726
 protein coding gene Chr9:68029664-68248081 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035442
 protein coding gene Chr9:62167714-62386938 (-)
PWK/PhJ MGP_PWKPhJ_G0033636
 protein coding gene Chr9:60593796-60812144 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033470
 protein coding gene Chr9:62444741-62663187 (-)
WSB/EiJ MGP_WSBEiJ_G0034045
 protein coding gene Chr9:62075560-62292275 (-)



Homology
more
  • Human Ortholog
    MAP2K5, mitogen-activated protein kinase kinase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP2K5, mitogen-activated protein kinase kinase 5
  • Synonyms
    HsT17454, MAPKK5, MEK5, PRKMK5
  • Links
    NCBI Gene ID: 5607
    neXtProt AC: NX_Q13163
    UniProt: Q13163

  • Chr Location
    15q23; chr15:67542703-67807117 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants die at E10.5 and exhibit abnormal cardiac development and a decrease in proliferation and an increase in apoptosis in the heart, head, and dorsal regions of the embryo.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    26
  • cDNA Data
    43
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000058444 Ensembl Gene Model | MGI Sequence Detail 214135 C57BL/6J ±  kb
    transcript ENSMUST00000034920 Ensembl | MGI Sequence Detail 2310 Not Applicable  
    polypeptide ENSMUSP00000034920 Ensembl | MGI Sequence Detail 448 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 45
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2143021, MGI:2143042
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 9
      Gene Ontology 14
      Phenotypes 15
    • Earliest
      J:57565 Kamakura S, et al., Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. J Biol Chem. 1999 Sep 10;274(37):26563-71
    • Latest
      J:339061 Tsitsikov EN, et al., TRAF7 is an essential regulator of blood vessel integrity during mouse embryonic and neonatal development. iScience. 2023 Aug 18;26(8):107474
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory