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Mapk8 Gene Detail
Summary
  • Symbol
    Mapk8
  • Name
    mitogen-activated protein kinase 8
  • Synonyms
    c-Jun N-terminal kinase, JNK1, Prkm8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346861
    NCBI Gene: 26419
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:33099855-33169115 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 20.22 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1224 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346861
 protein coding gene Chr14:33099855-33169213 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021156
 protein coding gene Chr14:26678871-26758649 (-)
A/J MGP_AJ_G0021104
 protein coding gene Chr14:25657706-25727463 (-)
AKR/J MGP_AKRJ_G0021081
 protein coding gene Chr14:26801233-26876795 (-)
BALB/cJ MGP_BALBcJ_G0021108
 protein coding gene Chr14:25825210-25896079 (-)
C3H/HeJ MGP_C3HHeJ_G0020891
 protein coding gene Chr14:26710556-26781137 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021540
 protein coding gene Chr14:27731502-27806679 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019102
 protein coding gene Chr14:25694461-25771061 (-)
CAST/EiJ MGP_CASTEiJ_G0020416
 protein coding gene Chr14:26522552-26593003 (-)
CBA/J MGP_CBAJ_G0020858
 protein coding gene Chr14:28757961-28828385 (-)
DBA/2J MGP_DBA2J_G0020980
 protein coding gene Chr14:25695092-25763337 (-)
FVB/NJ MGP_FVBNJ_G0020964
 protein coding gene Chr14:25645475-25713414 (-)
LP/J MGP_LPJ_G0021049
 protein coding gene Chr14:26998550-27070194 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020990
 protein coding gene Chr14:27919876-27996228 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021573
 protein coding gene Chr14:26624831-26704895 (-)
PWK/PhJ MGP_PWKPhJ_G0020164
 protein coding gene Chr14:25164841-25238683 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019988
 protein coding gene Chr14:26259908-26330137 (-)
WSB/EiJ MGP_WSBEiJ_G0020471
 protein coding gene Chr14:26692041-26765465 (-)



Homology
more
  • Human Ortholog
    MAPK8, mitogen-activated protein kinase 8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAPK8, mitogen-activated protein kinase 8
  • Synonyms
    JNK, JNK1, JNK1A2, JNK21B1/2, JNK-46, PRKM8, SAPK1, SAPK1c
  • Links
    NCBI Gene ID: 5599
    neXtProt AC: NX_P45983
    UniProt: P45983

  • Chr Location
    10q11.22; chr10:48306639-48439360 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human MAPK8 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    52 phenotypes from 4 alleles in 10 genetic backgrounds
    95 phenotypes from multigenic genotypes
    4 images
    219 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal T cell differentiation and proliferation, cardiac morphology and physiology, and chemically-induced tumorigenesis. Mice homozygous for another knock-out allele exhibit abnormal glucose homeostasis and T cell physiology. KO also leads to an increased number of retinal photoreceptor cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    125
  • GO References
    48
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1139
  • Tissues
    137
  • cDNA Data
    82
  • Literature Summary
    155
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021936 Ensembl Gene Model | MGI Sequence Detail 69261 C57BL/6J ±  kb
    transcript ENSMUST00000022504 Ensembl | MGI Sequence Detail 2587 Not Applicable  
    polypeptide ENSMUSP00000022504 Ensembl | MGI Sequence Detail 427 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 91
      Genomic 1
      cDNA 85
      Primer pair 4
      Other 1

      Microarray probesets 12
    Other
    Accession IDs
    less
    MGI:1328367, MGI:2145699
    References
    more
    • Summaries
      All 624
      Developmental Gene Expression 155
      Diseases 1
      Gene Ontology 48
      Phenotypes 219
    • Earliest
      J:41744 Tournier C, et al., Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7337-42
    • Latest
      J:352991 Wang J, et al., Crosstalk of MAP3K1 and EGFR signaling mediates gene-environment interactions that block developmental tissue closure. J Biol Chem. 2024 Jul;300(7):107486
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory