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Mapk9 Gene Detail
Summary
  • Symbol
    Mapk9
  • Name
    mitogen-activated protein kinase 9
  • Synonyms
    c-Jun N-terminal kinase, JNK2, JNK/SAPK alpha, Prkm9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346862
    NCBI Gene: 26420
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:49737578-49777248 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 29.96 cM, cytoband B1.2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    987 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346862
 protein coding gene Chr11:49737558-49777248 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018238
 protein coding gene Chr11:48995840-49035506 (+)
A/J MGP_AJ_G0018206
 protein coding gene Chr11:47116384-47158443 (+)
AKR/J MGP_AKRJ_G0018176
 protein coding gene Chr11:48621768-48663727 (+)
BALB/cJ MGP_BALBcJ_G0018176
 protein coding gene Chr11:47396889-47436325 (+)
C3H/HeJ MGP_C3HHeJ_G0017989
 protein coding gene Chr11:48613878-48653543 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018627
 protein coding gene Chr11:50449844-50492214 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016279
 protein coding gene Chr11:44735816-44775377 (+)
CAST/EiJ MGP_CASTEiJ_G0017551
 protein coding gene Chr11:48587905-48626747 (+)
CBA/J MGP_CBAJ_G0017964
 protein coding gene Chr11:52787105-52826732 (+)
DBA/2J MGP_DBA2J_G0018071
 protein coding gene Chr11:46920154-46959889 (+)
FVB/NJ MGP_FVBNJ_G0018065
 protein coding gene Chr11:46538798-46578416 (+)
LP/J MGP_LPJ_G0018146
 protein coding gene Chr11:49331705-49371266 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018090
 protein coding gene Chr11:54327748-54372204 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018671
 protein coding gene Chr11:48720525-48760130 (+)
PWK/PhJ MGP_PWKPhJ_G0017329
 protein coding gene Chr11:47307884-47347960 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017124
 protein coding gene Chr11:48423273-48462610 (+)
WSB/EiJ MGP_WSBEiJ_G0017604
 protein coding gene Chr11:48365715-48410899 (+)



Homology
more
  • Human Ortholog
    MAPK9, mitogen-activated protein kinase 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAPK9, mitogen-activated protein kinase 9
  • Synonyms
    JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, JNK-55, p54a, p54aSAPK, PRKM9, SAPK, SAPK1a
  • Links
    NCBI Gene ID: 5601
    neXtProt AC: NX_P45984
    UniProt: P45984

  • Chr Location
    5q35.3; chr5:180233143-180292099 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human MAPK9 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 8 genetic backgrounds
    103 phenotypes from multigenic genotypes
    4 images
    185 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show resistance to TNF-induced liver injury, impaired TH1 cell differentiation, and enhanced epidermal differentiation and proliferation. Homozygotes for a reporter allele show impaired T-cell activation and apoptosis, resistance to I-R cardiac injury, and reduced LTP.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    74
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    965
  • Tissues
    91
  • cDNA Data
    149
  • Literature Summary
    61
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020366 Ensembl Gene Model | MGI Sequence Detail 39671 C57BL/6J ±  kb
    transcript ENSMUST00000178543 Ensembl | MGI Sequence Detail 4677 Not Applicable  
    polypeptide ENSMUSP00000136977 Ensembl | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 153
      cDNA 151
      Primer pair 1
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1202396, MGI:2144306
    References
    more
    • Summaries
      All 331
      Developmental Gene Expression 61
      Diseases 1
      Gene Ontology 19
      Phenotypes 185
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:352991 Wang J, et al., Crosstalk of MAP3K1 and EGFR signaling mediates gene-environment interactions that block developmental tissue closure. J Biol Chem. 2024 Jul;300(7):107486
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory