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Map2k6 Gene Detail
Summary
  • Symbol
    Map2k6
  • Name
    mitogen-activated protein kinase kinase 6
  • Synonyms
    MAP kinase kinase 6, MKK6, Prkmk6, SAPKK3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346870
    NCBI Gene: 26399
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:110289948-110416348 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 73.60 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4342 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346870
 protein coding gene Chr11:110289928-110416348 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019345
 protein coding gene Chr11:114027286-114159835 (+)
A/J MGP_AJ_G0019313
 protein coding gene Chr11:109090449-109217932 (+)
AKR/J MGP_AKRJ_G0019282
 protein coding gene Chr11:112352135-112490062 (+)
BALB/cJ MGP_BALBcJ_G0019287
 protein coding gene Chr11:109525949-109655105 (+)
C3H/HeJ MGP_C3HHeJ_G0019096
 protein coding gene Chr11:112656369-112806706 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019737
 protein coding gene Chr11:117461918-117601753 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017360
 protein coding gene Chr11:106269380-106397495 (+)
CAST/EiJ MGP_CASTEiJ_G0018649
 protein coding gene Chr11:113753290-113956835 (+)
CBA/J MGP_CBAJ_G0019065
 protein coding gene Chr11:122322745-122471375 (+)
DBA/2J MGP_DBA2J_G0019177
 protein coding gene Chr11:108572094-108701102 (+)
FVB/NJ MGP_FVBNJ_G0019168
 protein coding gene Chr11:108021860-108148469 (+)
LP/J MGP_LPJ_G0019247
 protein coding gene Chr11:114427467-114561600 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019199
 protein coding gene Chr11:121443850-121578820 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019774
 protein coding gene Chr11:112936468-113067173 (+)
PWK/PhJ MGP_PWKPhJ_G0018414
 protein coding gene Chr11:109724983-109859409 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018206
 protein coding gene Chr11:112736224-112883326 (+)
WSB/EiJ MGP_WSBEiJ_G0018701
 protein coding gene Chr11:112863736-113004306 (+)



Homology
more
  • Human Ortholog
    MAP2K6, mitogen-activated protein kinase kinase 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP2K6, mitogen-activated protein kinase kinase 6
  • Synonyms
    MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3
  • Links
    NCBI Gene ID: 5608
    neXtProt AC: NX_P52564
    UniProt: P52564

  • Chr Location
    17q24.3; chr17:69414697-69553865 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human MAP2K6 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null targeted mutations of this gene are viable, grow normally and have no gross physical or histologic abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    887
  • Tissues
    170
  • cDNA Data
    41
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020623 Ensembl Gene Model | MGI Sequence Detail 126401 C57BL/6J ±  kb
    transcript ENSMUST00000020949 Ensembl | MGI Sequence Detail 2068 Not Applicable  
    polypeptide ENSMUSP00000020949 Ensembl | MGI Sequence Detail 334 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 43
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37068, MGI:108032
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 14
      Gene Ontology 17
      Phenotypes 25
    • Earliest
      J:36237 Han J, et al., Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J Biol Chem. 1996 Feb 9;271(6):2886-91
    • Latest
      J:334031 Crespo M, et al., Myeloid p38 activation maintains macrophage-liver crosstalk and BAT thermogenesis through IL-12-FGF21 axis. Hepatology. 2023 Mar 1;77(3):874-887
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory