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Map4k1 Gene Detail
Summary
  • Symbol
    Map4k1
  • Name
    mitogen-activated protein kinase kinase kinase kinase 1
  • Synonyms
    Hpk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346882
    NCBI Gene: 26411
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28681506-28702704 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.94 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    696 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346882
 protein coding gene Chr7:28681475-28702704 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031969
 protein coding gene Chr7:27870869-27895379 (+)
A/J MGP_AJ_G0031947
 protein coding gene Chr7:27140703-27161577 (+)
AKR/J MGP_AKRJ_G0031879
 protein coding gene Chr7:27841980-27867177 (+)
BALB/cJ MGP_BALBcJ_G0031954
 protein coding gene Chr7:27293881-27317808 (+)
C3H/HeJ MGP_C3HHeJ_G0031673
 protein coding gene Chr7:28245807-28266065 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032418
 protein coding gene Chr7:28755039-28775171 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029470
 protein coding gene Chr7:28201112-28221473 (+)
CAST/EiJ MGP_CASTEiJ_G0031008
 protein coding gene Chr7:21538815-21561136 (+)
CBA/J MGP_CBAJ_G0031639
 protein coding gene Chr7:30108271-30133662 (+)
DBA/2J MGP_DBA2J_G0031791
 protein coding gene Chr7:26886070-26906607 (+)
FVB/NJ MGP_FVBNJ_G0031748
 protein coding gene Chr7:26975497-26997685 (+)
LP/J MGP_LPJ_G0031871
 protein coding gene Chr7:28170339-28191838 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031784
 protein coding gene Chr7:29494170-29517218 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032448
 protein coding gene Chr7:27325955-27345758 (+)
PWK/PhJ MGP_PWKPhJ_G0030733
 protein coding gene Chr7:21924029-21945000 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030566
 protein coding gene Chr7:18349767-18373576 (+)
WSB/EiJ MGP_WSBEiJ_G0031117
 protein coding gene Chr7:27700749-27722603 (+)



Homology
more
  • Human Ortholog
    MAP4K1, mitogen-activated protein kinase kinase kinase kinase 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP4K1, mitogen-activated protein kinase kinase kinase kinase 1
  • Synonyms
    HPK1
  • Links
    NCBI Gene ID: 11184
    neXtProt AC: NX_Q92918
    UniProt: Q92918

  • Chr Location
    19q13.2; chr19:38587641-38618882 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 4 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have increased responses of B and T cells. Dendritic cells are also hyperresponsive to stimulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    49
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    862
  • Tissues
    143
  • cDNA Data
    38
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 26411 NCBI Gene Model | MGI Sequence Detail 21199 C57BL/6J ±  kb
transcript NM_008279 RefSeq | MGI Sequence Detail 2700 C57BL/6  
polypeptide P70218 UniProt | EBI | MGI Sequence Detail 827 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 40
    cDNA 39
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-38203, MGI:109159
References
more
  • Summaries
    All 48
    Developmental Gene Expression 4
    Gene Ontology 10
    Phenotypes 17
  • Earliest
    J:37543 Kiefer F, et al., HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. EMBO J. 1996 Dec 16;15(24):7013-25
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory