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Nubp1 Gene Detail
Summary
  • Symbol
    Nubp1
  • Name
    nucleotide binding protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347073
    NCBI Gene: 26425
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:10229812-10242292 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 5.61 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    518 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347073
 protein coding gene Chr16:10229802-10242317 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022506
 protein coding gene Chr16:7204590-7217066 (+)
A/J MGP_AJ_G0022468
 protein coding gene Chr16:6812249-6824751 (+)
AKR/J MGP_AKRJ_G0022444
 protein coding gene Chr16:7132675-7145171 (+)
BALB/cJ MGP_BALBcJ_G0022472
 protein coding gene Chr16:6949695-6962169 (+)
C3H/HeJ MGP_C3HHeJ_G0022239
 protein coding gene Chr16:7213912-7226384 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022921
 protein coding gene Chr16:7361462-7375278 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020442
 protein coding gene Chr16:6953396-6966019 (+)
CAST/EiJ MGP_CASTEiJ_G0021766
 protein coding gene Chr16:7215855-7228393 (+)
CBA/J MGP_CBAJ_G0022208
 protein coding gene Chr16:7675835-7688307 (+)
DBA/2J MGP_DBA2J_G0022339
 protein coding gene Chr16:6825716-6838188 (+)
FVB/NJ MGP_FVBNJ_G0022315
 protein coding gene Chr16:6805613-6818092 (+)
LP/J MGP_LPJ_G0022407
 protein coding gene Chr16:7164913-7177386 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022337
 protein coding gene Chr16:7410260-7422733 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022934
 protein coding gene Chr16:7080124-7092601 (+)
PWK/PhJ MGP_PWKPhJ_G0021506
 protein coding gene Chr16:7019582-7032516 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021336
 protein coding gene Chr16:7134506-7146986 (+)
WSB/EiJ MGP_WSBEiJ_G0021814
 protein coding gene Chr16:7145077-7157553 (+)



Homology
more
  • Human Ortholog
    NUBP1, NUBP iron-sulfur cluster assembly factor 1, cytosolic
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUBP1, NUBP iron-sulfur cluster assembly factor 1, cytosolic
  • Synonyms
    CIAO5, NBP, NBP1, NBP35
  • Links
    NCBI Gene ID: 4682
    neXtProt AC: NX_P53384
    UniProt: P53384

  • Chr Location
    16p13.13; chr16:10743786-10769351 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU induced mutation display neonatal lethality, respiratory failure, severe lung hypoplasia, impaired lung development, syndactyly and oligodactyly.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    13
  • cDNA Data
    10
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022503 Ensembl Gene Model | MGI Sequence Detail 12481 C57BL/6J ±  kb
    transcript ENSMUST00000023146 Ensembl | MGI Sequence Detail 2121 Not Applicable  
    polypeptide ENSMUSP00000023146 Ensembl | MGI Sequence Detail 320 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000011476 cytosolic Fe-S cluster assembly factor NUBP1
      (term hierarchy)
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR028601 Cytosolic Fe-S cluster assembly factor NUBP1/Nbp35
      IPR033756 Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35
      IPR000808 Iron-sulfur cluster carrier protein-like, conserved site
      IPR019591 Mrp/NBP35 ATP-binding protein
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      Q9R060 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 2

      Microarray probesets 9
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 6
    • Earliest
      J:57779 Nakashima H, et al., Two novel mouse genes--Nubp2, mapped to the t-complex on chromosome 17, and Nubp1, mapped to chromosome 16--establish a new gene family of nucleotide-binding proteins in eukaryotes. Genomics. 1999 Sep 1;60(2):152-60
    • Latest
      J:346140 Zhao Y, et al., Nr5a2 ensures inner cell mass formation in mouse blastocyst. Cell Rep. 2024 Feb 21;43(3):113840
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory