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Parg Gene Detail
Summary
  • Symbol
    Parg
  • Name
    poly (ADP-ribose) glycohydrolase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347094
    NCBI Gene: 26430
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:31923906-32019507 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 19.40 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2243 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347094
 protein coding gene Chr14:31923900-32020671 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021142
 protein coding gene Chr14:25436313-25537454 (+)
A/J MGP_AJ_G0021090
 protein coding gene Chr14:24467421-24563765 (+)
AKR/J MGP_AKRJ_G0021067
 protein coding gene Chr14:25615348-25711132 (+)
BALB/cJ MGP_BALBcJ_G0021094
 protein coding gene Chr14:24644267-24741146 (+)
C3H/HeJ MGP_C3HHeJ_G0020877
 protein coding gene Chr14:25488842-25585592 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021526
 protein coding gene Chr14:26452698-26566122 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019089
 protein coding gene Chr14:24530744-24632519 (+)
CAST/EiJ MGP_CASTEiJ_G0020402
 protein coding gene Chr14:25280876-25380449 (+)
CBA/J MGP_CBAJ_G0020844
 protein coding gene Chr14:27439277-27544965 (+)
DBA/2J MGP_DBA2J_G0020966
 protein coding gene Chr14:24498261-24596490 (+)
FVB/NJ MGP_FVBNJ_G0020950
 protein coding gene Chr14:24462834-24558781 (+)
LP/J MGP_LPJ_G0021035
 protein coding gene Chr14:25757765-25858644 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020976
 protein coding gene Chr14:26675425-26780514 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021559
 protein coding gene Chr14:25386363-25486455 (+)
PWK/PhJ MGP_PWKPhJ_G0020150
 protein coding gene Chr14:23971036-24070597 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019974
 protein coding gene Chr14:24995683-25099035 (+)
WSB/EiJ MGP_WSBEiJ_G0020457
 protein coding gene Chr14:25447937-25551189 (+)



Homology
more
  • Human Ortholog
    PARG, poly(ADP-ribose) glycohydrolase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PARG, poly(ADP-ribose) glycohydrolase
  • Synonyms
    PARG99
  • Links
    NCBI Gene ID: 8505
    neXtProt AC: NX_Q86W56
    UniProt: Q86W56

  • Chr Location
    10q11.23; chr10:49818279-49970203 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 4 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one allele of this gene are hypersensitive to alkylating agents and ionizing radiation and susceptible to streptozotocin induced diabetes and endotoxic shock. Mice homozygous for a second allele display embryonic lethality and fail tohatch from the zona pellucida.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    739
  • Tissues
    26
  • cDNA Data
    14
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021911 Ensembl Gene Model | MGI Sequence Detail 95602 C57BL/6J ±  kb
    transcript ENSMUST00000022470 Ensembl | MGI Sequence Detail 4413 Not Applicable  
    polypeptide ENSMUSP00000022470 Ensembl | MGI Sequence Detail 961 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145628
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 24
    • Earliest
      J:57240 Ame JC, et al., Assignment of the poly(ADP-ribose) glycohydrolase gene (PARG) to human chromosome 10q11.23 and mouse chromosome 14B by in situ hybridization. Cytogenet Cell Genet. 1999;85(3-4):269-70
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory