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Homer1 Gene Detail
Summary
  • Symbol
    Homer1
  • Name
    homer scaffolding protein 1
  • Synonyms
    PSD-Zip45, Ves-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347345
    NCBI Gene: 26556
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:93436143-93541637 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 47.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2245 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347345
 protein coding gene Chr13:93436143-93549471 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020824
 protein coding gene Chr13:94634931-94738411 (+)
A/J MGP_AJ_G0020778
 protein coding gene Chr13:91124135-91224036 (+)
AKR/J MGP_AKRJ_G0020751
 protein coding gene Chr13:93905870-94007267 (+)
BALB/cJ MGP_BALBcJ_G0020774
 protein coding gene Chr13:91772033-91872829 (+)
C3H/HeJ MGP_C3HHeJ_G0020568
 protein coding gene Chr13:93583150-93689310 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021211
 protein coding gene Chr13:97526680-97630163 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018778
 protein coding gene Chr13:87018717-87116756 (+)
CAST/EiJ MGP_CASTEiJ_G0020087
 protein coding gene Chr13:92841480-92952952 (+)
CBA/J MGP_CBAJ_G0020527
 protein coding gene Chr13:101377128-101493272 (+)
DBA/2J MGP_DBA2J_G0020652
 protein coding gene Chr13:90905078-91006402 (+)
FVB/NJ MGP_FVBNJ_G0020632
 protein coding gene Chr13:89702946-89803652 (+)
LP/J MGP_LPJ_G0020725
 protein coding gene Chr13:94753507-94859421 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020661
 protein coding gene Chr13:101884612-102018016 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021251
 protein coding gene Chr13:93281294-93381554 (+)
PWK/PhJ MGP_PWKPhJ_G0019839
 protein coding gene Chr13:89610072-89711762 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019663
 protein coding gene Chr13:89557371-89669645 (+)
WSB/EiJ MGP_WSBEiJ_G0020144
 protein coding gene Chr13:93776355-93880662 (+)



Homology
more
  • Human Ortholog
    HOMER1, homer scaffold protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOMER1, homer scaffold protein 1
  • Synonyms
    HOMER, HOMER1A, HOMER1B, HOMER1C, SYN47, Ves-1
  • Links
    NCBI Gene ID: 9456
    neXtProt AC: NX_Q86YM7
    UniProt: Q86YM7

  • Chr Location
    5q14.1; chr5:79372636-79514134 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit an increase in spontaneous calcium influx in pancreatic acinar cells. Mice homozygous for a knock-out allele exhibit decreased response to formalin-induced pain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    976
  • Tissues
    195
  • cDNA Data
    36
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000007617 Ensembl Gene Model | MGI Sequence Detail 105495 C57BL/6J ±  kb
    transcript ENSMUST00000079086 Ensembl | MGI Sequence Detail 4287 Not Applicable  
    polypeptide ENSMUSP00000078093 Ensembl | MGI Sequence Detail 370 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 36
      Primer pair 1
      Other 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 16
      Gene Ontology 27
      Phenotypes 36
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:342051 Koutsioumpa C, et al., Skin-type-dependent development of murine mechanosensory neurons. Dev Cell. 2023 Oct 23;58(20):2032-2047.e6
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory