About   Help   FAQ
Foxg1 Gene Detail
Summary
  • Symbol
    Foxg1
  • Name
    forkhead box G1
  • Synonyms
    2900064B05Rik, Bf1, BF-1, Hfh9, Hfhbf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347464
    NCBI Gene: 15228
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:49429666-49433650 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 21.78 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347464
 protein coding gene Chr12:49429443-49433650 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019717
 protein coding gene Chr12:48107306-48111453 (+)
A/J MGP_AJ_G0019680
 protein coding gene Chr12:46402739-46406901 (+)
AKR/J MGP_AKRJ_G0019651
 protein coding gene Chr12:47774597-47778781 (+)
BALB/cJ MGP_BALBcJ_G0019658
 protein coding gene Chr12:46660378-46664580 (+)
C3H/HeJ MGP_C3HHeJ_G0019461
 protein coding gene Chr12:47880478-47884610 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020104
 protein coding gene Chr12:49549399-49553545 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017729
 protein coding gene Chr12:44995331-44999484 (+)
CAST/EiJ MGP_CASTEiJ_G0019014
 protein coding gene Chr12:42946078-42950099 (+)
CBA/J MGP_CBAJ_G0019433
 protein coding gene Chr12:51254029-51258159 (+)
DBA/2J MGP_DBA2J_G0019547
 protein coding gene Chr12:46251447-46255592 (+)
FVB/NJ MGP_FVBNJ_G0019536
 protein coding gene Chr12:45752391-45756553 (+)
LP/J MGP_LPJ_G0019616
 protein coding gene Chr12:48117035-48121587 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019572
 protein coding gene Chr12:52694225-52699493 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020144
 protein coding gene Chr12:47332846-47337009 (+)
PWK/PhJ MGP_PWKPhJ_G0018781
 protein coding gene Chr12:40830168-40834568 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018573
 protein coding gene Chr12:41898725-41902859 (+)
WSB/EiJ MGP_WSBEiJ_G0019064
 protein coding gene Chr12:47749042-47753180 (+)



Homology
more
  • Human Ortholog
    FOXG1, forkhead box G1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXG1, forkhead box G1
  • Synonyms
    BF1, BF2, FHKL3, FKH2, FKHL1, FKHL2, FKHL3, FKHL4, FOXG1A, FOXG1B, FOXG1C, HBF-1, HBF-2, HBF2, HBF-3, HBF-G2, HFK1, HFK2, HFK3, KHL2, QIN
  • Links
    NCBI Gene ID: 2290
    neXtProt AC: NX_P55316
    UniProt: P55316

  • Chr Location
    14q12; chr14:28764329-28770277 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Foxg1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 3 alleles in 7 genetic backgrounds
    222 phenotypes from multigenic genotypes
    2 images
    355 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit dramatically reduced cerebral hemispheres, missing ventral telencephalic structures, impaired migration of efferent thalamocortical axons, and multiple eye defects. Mutants die at birth from respiratory failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1346
  • Tissues
    264
  • cDNA Data
    31
  • Literature Summary
    244
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15228 NCBI Gene Model | MGI Sequence Detail 3985 C57BL/6J ±  kb
    transcript NM_001160112 RefSeq | MGI Sequence Detail 3986 ZRU/MplStud  
    polypeptide Q60987 UniProt | EBI | MGI Sequence Detail 481 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      Genomic 4
      cDNA 45
      Primer pair 8
      Other 23

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16692, MGI:1920272, MGI:99896
    References
    more
    • Summaries
      All 580
      Developmental Gene Expression 244
      Diseases 6
      Gene Ontology 20
      Phenotypes 355
    • Earliest
      J:20861 Tao W, et al., Telencephalon-restricted expression of BF-1, a new member of the HNF-3/fork head gene family, in the developing rat brain. Neuron. 1992 May;8(5):957-66
    • Latest
      J:358820 Dudukcu O, et al., Molecular diversity and migration of GABAergic neurons in the developing ventral midbrain. iScience. 2024 Nov 15;27(11):111239
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory