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Foxh1 Gene Detail
Summary
  • Symbol
    Foxh1
  • Name
    forkhead box H1
  • Synonyms
    Fast2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347465
    NCBI Gene: 14106
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:76552425-76554148 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 36.24 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347465
 protein coding gene Chr15:76552029-76554286 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022005
 protein coding gene Chr15:76761671-76763335 (-)
A/J MGP_AJ_G0021963
 protein coding gene Chr15:73955442-73957106 (-)
AKR/J MGP_AKRJ_G0021946
 protein coding gene Chr15:75962257-75963921 (-)
BALB/cJ MGP_BALBcJ_G0021972
 protein coding gene Chr15:73981081-73982745 (-)
C3H/HeJ MGP_C3HHeJ_G0021744
 protein coding gene Chr15:76007353-76009017 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022412
 protein coding gene Chr15:79626024-79627688 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019941
 protein coding gene Chr15:70612799-70614463 (-)
CAST/EiJ MGP_CASTEiJ_G0021263
 protein coding gene Chr15:76811870-76813534 (-)
CBA/J MGP_CBAJ_G0021711
 protein coding gene Chr15:82152334-82153998 (-)
DBA/2J MGP_DBA2J_G0021836
 protein coding gene Chr15:73492489-73494153 (-)
FVB/NJ MGP_FVBNJ_G0021816
 protein coding gene Chr15:72550625-72552289 (-)
LP/J MGP_LPJ_G0021907
 protein coding gene Chr15:76851098-76852762 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021841
 protein coding gene Chr15:87481799-87483463 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022432
 protein coding gene Chr15:76237080-76238744 (-)
PWK/PhJ MGP_PWKPhJ_G0021004
 protein coding gene Chr15:73657572-73659236 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020844
 protein coding gene Chr15:75931585-75933250 (-)
WSB/EiJ MGP_WSBEiJ_G0021315
 protein coding gene Chr15:76324064-76325728 (-)



Homology
more
  • Human Ortholog
    FOXH1, forkhead box H1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXH1, forkhead box H1
  • Synonyms
    FAST-1, FAST1
  • Links
    NCBI Gene ID: 8928
    neXtProt AC: NX_O75593
    UniProt: O75593

  • Chr Location
    8q24.3; chr8:144473412-144475849 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Foxh1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    75 phenotypes from 6 alleles in 4 genetic backgrounds
    24 images
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Conditional knockout of this gene in the lateral plate mesoderm results in death within a few days after birth. Mutant animals exhibit right isomerism affecting the heart, lungs, and stomach.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    854
  • Tissues
    114
  • cDNA Data
    11
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033837 Ensembl Gene Model | MGI Sequence Detail 1724 C57BL/6J ±  kb
    transcript ENSMUST00000037824 Ensembl | MGI Sequence Detail 1365 Not Applicable  
    polypeptide ENSMUSP00000036591 Ensembl | MGI Sequence Detail 401 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 2
      cDNA 11
      Primer pair 3
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1277981
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 28
      Diseases 2
      Gene Ontology 14
      Phenotypes 46
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:354455 Chen X, et al., SENP3-regulated Nodal signaling plays a potential role in cardiac left-right asymmetry development. Int J Biol Macromol. 2024 Aug;274(Pt 2):133294
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory