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Ror1 Gene Detail
Summary
  • Symbol
    Ror1
  • Name
    receptor tyrosine kinase-like orphan receptor 1
  • Synonyms
    2810404D04Rik, Ntrkr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347520
    NCBI Gene: 26563
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:99952988-100301962 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 45.71 cM, cytoband C6
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9701 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347520
 protein coding gene Chr4:99952988-100302003 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028486
 protein coding gene Chr4:100340734-100718845 (+)
A/J MGP_AJ_G0028449
 protein coding gene Chr4:96836388-97198607 (+)
AKR/J MGP_AKRJ_G0028396
 protein coding gene Chr4:99180729-99531693 (+)
BALB/cJ MGP_BALBcJ_G0028467
 protein coding gene Chr4:97077015-97436805 (+)
C3H/HeJ MGP_C3HHeJ_G0028180
 protein coding gene Chr4:100003719-100370741 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028906
 protein coding gene Chr4:104142369-104536712 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026198
 protein coding gene Chr4:92191190-92539811 (+)
CAST/EiJ MGP_CASTEiJ_G0027620
 protein coding gene Chr4:97792164-98155228 (+)
CBA/J MGP_CBAJ_G0028149
 protein coding gene Chr4:107401224-107813741 (+)
DBA/2J MGP_DBA2J_G0028299
 protein coding gene Chr4:96554165-96903440 (+)
FVB/NJ MGP_FVBNJ_G0028266
 protein coding gene Chr4:95392163-95743947 (+)
LP/J MGP_LPJ_G0028399
 protein coding gene Chr4:100646962-101022001 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028294
 protein coding gene Chr4:113009185-113404173 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028944
 protein coding gene Chr4:99438407-99810858 (+)
PWK/PhJ MGP_PWKPhJ_G0027345
 protein coding gene Chr4:94713570-95072953 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027167
 protein coding gene Chr4:96887697-97255476 (+)
WSB/EiJ MGP_WSBEiJ_G0027698
 protein coding gene Chr4:99602983-99970942 (+)



Homology
more
  • Human Ortholog
    ROR1, receptor tyrosine kinase like orphan receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ROR1, receptor tyrosine kinase like orphan receptor 1
  • Synonyms
    dJ537F10.1, NTRKR1
  • Links
    NCBI Gene ID: 4919
    neXtProt AC: NX_Q01973
    UniProt: Q01973

  • Chr Location
    1p31.3; chr1:63774017-64181498 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ROR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 3 alleles in 4 genetic backgrounds
    20 phenotypes from multigenic genotypes
    4 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for some disruptions in this gene die within the first day after birth from respiratory defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1027
  • Tissues
    268
  • cDNA Data
    13
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035305 Ensembl Gene Model | MGI Sequence Detail 348975 C57BL/6J ±  kb
    transcript ENSMUST00000039630 Ensembl | MGI Sequence Detail 5762 Not Applicable  
    polypeptide ENSMUSP00000048171 Ensembl | MGI Sequence Detail 937 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 13
      Primer pair 2
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1919426
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 21
      Gene Ontology 10
      Phenotypes 27
    • Earliest
      J:57217 Oishi I, et al., Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system. Genes Cells. 1999 Jan;4(1):41-56
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory