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Tssk2 Gene Detail
Summary
  • Symbol
    Tssk2
  • Name
    testis-specific serine kinase 2
  • Synonyms
    DGS-G, SPOGA2, Stk22b, Tsk2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347559
    NCBI Gene: 22115
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17716501-17717888 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.09 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    17 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347559
 protein coding gene Chr16:17716501-17717888 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022596
 protein coding gene Chr16:15085513-15086899 (+)
A/J MGP_AJ_G0022557
 protein coding gene Chr16:14334323-14335709 (+)
AKR/J MGP_AKRJ_G0022534
 protein coding gene Chr16:14893998-14895384 (+)
BALB/cJ MGP_BALBcJ_G0022560
 protein coding gene Chr16:14487447-14488833 (+)
C3H/HeJ MGP_C3HHeJ_G0022327
 protein coding gene Chr16:15040580-15041966 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023011
 protein coding gene Chr16:15327763-15329149 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020531
 protein coding gene Chr16:14392529-14393935 (+)
CAST/EiJ MGP_CASTEiJ_G0021855
 protein coding gene Chr16:14957107-14958493 (+)
CBA/J MGP_CBAJ_G0022298
 protein coding gene Chr16:16001157-16002543 (+)
DBA/2J MGP_DBA2J_G0022428
 protein coding gene Chr16:14246637-14248023 (+)
FVB/NJ MGP_FVBNJ_G0022404
 protein coding gene Chr16:14296740-14298190 (+)
LP/J MGP_LPJ_G0022495
 protein coding gene Chr16:14868929-14870315 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022425
 protein coding gene Chr16:15680078-15681464 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023022
 protein coding gene Chr16:14839388-14840774 (+)
PWK/PhJ MGP_PWKPhJ_G0021598
 protein coding gene Chr16:14505535-14506921 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021426
 protein coding gene Chr16:14808711-14810097 (+)
WSB/EiJ MGP_WSBEiJ_G0021902
 protein coding gene Chr16:14823762-14825148 (+)



Homology
more
  • Human Ortholog
    TSSK2, testis specific serine kinase 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSSK2, testis specific serine kinase 2
  • Synonyms
    DGS-G, SPOGA2, STK22B, TSK2
  • Links
    NCBI Gene ID: 23617
    neXtProt AC: NX_Q96PF2
    UniProt: Q96PF2

  • Chr Location
    22q11.21; chr22:19131308-19132622 (+)  GRCh38
Human Diseases
less
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a knock-out allele of Tssk1 and 2 are infertile due to arrested spermatogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    43
  • cDNA Data
    19
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22115 NCBI Gene Model | MGI Sequence Detail 1388 C57BL/6J ±  kb
    transcript NM_009436 RefSeq | MGI Sequence Detail 1403 ZRU/MplStud  
    polypeptide O54863 UniProt | EBI | MGI Sequence Detail 358 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 10
      cDNA 20
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:892906
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 4
      Diseases 4
      Gene Ontology 10
      Phenotypes 53
    • Earliest
      J:38193 Galili N, et al., A region of mouse chromosome 16 is syntenic to the DiGeorge, velocardiofacial syndrome minimal critical region. (Correction: vol. 7(4):399). Genome Res. 1997 Jan;7(1):17-26
    • Latest
      J:342597 Rummell BP, et al., Altered corollary discharge signaling in the auditory cortex of a mouse model of schizophrenia predisposition. Nat Commun. 2023 Nov 15;14(1):7388
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory