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Foxl2 Gene Detail
Summary
  • Symbol
    Foxl2
  • Name
    forkhead box L2
  • Synonyms
    Pfrk
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349428
    NCBI Gene: 26927
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:98837495-98840601 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 51.41 cM, cytoband E4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    145 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349428
 protein coding gene Chr9:98837341-98840601 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035162
 protein coding gene Chr9:100285706-100288204 (+)
A/J MGP_AJ_G0035143
 protein coding gene Chr9:96757374-96758614 (+)
AKR/J MGP_AKRJ_G0035075
 protein coding gene Chr9:99124051-99125291 (+)
BALB/cJ MGP_BALBcJ_G0035136
 protein coding gene Chr9:96439261-96440501 (+)
C3H/HeJ MGP_C3HHeJ_G0034846
 protein coding gene Chr9:99515578-99516818 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035656
 protein coding gene Chr9:103163368-103164608 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032555
 protein coding gene Chr9:94508330-94509566 (+)
CAST/EiJ MGP_CASTEiJ_G0034157
 protein coding gene Chr9:99319804-99321037 (+)
CBA/J MGP_CBAJ_G0034814
 protein coding gene Chr9:106693467-106694707 (+)
DBA/2J MGP_DBA2J_G0034976
 protein coding gene Chr9:96276040-96277280 (+)
FVB/NJ MGP_FVBNJ_G0034924
 protein coding gene Chr9:95096660-95097900 (+)
LP/J MGP_LPJ_G0035052
 protein coding gene Chr9:100543792-100545032 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034963
 protein coding gene Chr9:108639208-108640448 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035678
 protein coding gene Chr9:99329017-99330249 (+)
PWK/PhJ MGP_PWKPhJ_G0033864
 protein coding gene Chr9:96473558-96474791 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033700
 protein coding gene Chr9:99411131-99412366 (+)
WSB/EiJ MGP_WSBEiJ_G0034277
 protein coding gene Chr9:99227974-99229214 (+)



Homology
more
  • Human Ortholog
    FOXL2, forkhead box L2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXL2, forkhead box L2
  • Synonyms
    BPES, BPES1, PFRK, PINTO, POF3
  • Links
    NCBI Gene ID: 668
    neXtProt AC: NX_P58012
    UniProt: P58012

  • Chr Location
    3q22.3; chr3:138944224-138947137 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Foxl2 mouse models; 3 with human FOXL2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 6 alleles in 8 genetic backgrounds
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display increased postnatal lethality. Of animals surving to mating age, males are fully fertile and females are infertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1327
  • Tissues
    197
  • cDNA Data
    12
  • Literature Summary
    172
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26927 NCBI Gene Model | MGI Sequence Detail 3107 C57BL/6J ±  kb
    transcript NM_012020 RefSeq | MGI Sequence Detail 3107 C57BL/6  
    polypeptide O88470 UniProt | EBI | MGI Sequence Detail 375 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 14
      Primer pair 17
      Other 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2143241
    References
    more
    • Summaries
      All 244
      Developmental Gene Expression 172
      Diseases 2
      Gene Ontology 17
      Phenotypes 50
    • Earliest
      J:48144 Treier M, et al., Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev. 1998 Jun 1;12(11):1691-704
    • Latest
      J:357896 Sheridan D, et al., Gonadotrophs have a dual origin, with most derived from pituitary stem cells during minipuberty. bioRxiv. 2024;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory