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Cul1 Gene Detail
Summary
  • Symbol
    Cul1
  • Name
    cullin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349658
    NCBI Gene: 26965
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:47430516-47503078 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 22.90 cM, cytoband B3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1062 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349658
 protein coding gene Chr6:47430332-47503078 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030681
 protein coding gene Chr6:46344483-46421182 (+)
A/J MGP_AJ_G0030653
 protein coding gene Chr6:44196145-44273500 (+)
AKR/J MGP_AKRJ_G0030578
 protein coding gene Chr6:45719631-45793355 (+)
BALB/cJ MGP_BALBcJ_G0030663
 protein coding gene Chr6:44550771-44625269 (+)
C3H/HeJ MGP_C3HHeJ_G0030376
 protein coding gene Chr6:45763824-45844732 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031118
 protein coding gene Chr6:47461054-47538479 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028324
 protein coding gene Chr6:41920166-41995071 (+)
CAST/EiJ MGP_CASTEiJ_G0029780
 protein coding gene Chr6:45620484-45694415 (+)
CBA/J MGP_CBAJ_G0030351
 protein coding gene Chr6:49360508-49443090 (+)
DBA/2J MGP_DBA2J_G0030500
 protein coding gene Chr6:44146381-44219633 (+)
FVB/NJ MGP_FVBNJ_G0030452
 protein coding gene Chr6:43779038-43854878 (+)
LP/J MGP_LPJ_G0030584
 protein coding gene Chr6:46250755-46325760 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030486
 protein coding gene Chr6:52252855-52333008 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031147
 protein coding gene Chr6:45661497-45738938 (+)
PWK/PhJ MGP_PWKPhJ_G0029492
 protein coding gene Chr6:43778270-43850672 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029328
 protein coding gene Chr6:45195081-45266781 (+)
WSB/EiJ MGP_WSBEiJ_G0029856
 protein coding gene Chr6:45641727-45716824 (+)



Homology
more
  • Human Ortholog
    CUL1, cullin 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CUL1, cullin 1
  • Links
    NCBI Gene ID: 8454
    neXtProt AC: NX_Q13616
    UniProt: Q13616

  • Chr Location
    7q36.1; chr7:148697756-148801110 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations accumulate cyclin E1 and exhibit arrested development and lethality around embryonic day 6.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    784
  • Tissues
    41
  • cDNA Data
    14
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26965 NCBI Gene Model | MGI Sequence Detail 72563 C57BL/6J ±  kb
    transcript NM_001355550 RefSeq | MGI Sequence Detail 3434 C57BL/6  
    polypeptide Q9WTX6 UniProt | EBI | MGI Sequence Detail 776 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 4
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 15
      Gene Ontology 14
      Phenotypes 8
    • Earliest
      J:48258 Michel JJ, et al., Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A. Cell Growth Differ. 1998 Jun;9(6):435-49
    • Latest
      J:335720 Li R, et al., Interaction between dual specificity phosphatase-1 and cullin-1 attenuates alcohol-related liver disease by restoring p62-mediated mitophagy. Int J Biol Sci. 2023;19(6):1831-1845
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory