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Irf5 Gene Detail
Summary
  • Symbol
    Irf5
  • Name
    interferon regulatory factor 5
  • Synonyms
    mirf5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1350924
    NCBI Gene: 27056
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:29526624-29541870 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 12.36 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    378 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1350924
 protein coding gene Chr6:29526129-29541874 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030527
 protein coding gene Chr6:27329837-27346367 (+)
A/J MGP_AJ_G0030500
 protein coding gene Chr6:26168519-26183668 (+)
AKR/J MGP_AKRJ_G0030427
 protein coding gene Chr6:27031368-27046508 (+)
BALB/cJ MGP_BALBcJ_G0030510
 protein coding gene Chr6:26325726-26341030 (+)
C3H/HeJ MGP_C3HHeJ_G0030223
 protein coding gene Chr6:27031153-27047065 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030964
 protein coding gene Chr6:28112030-28127275 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028175
 protein coding gene Chr6:24377161-24392940 (+)
CAST/EiJ MGP_CASTEiJ_G0029625
 protein coding gene Chr6:26834612-26850869 (+)
CBA/J MGP_CBAJ_G0030201
 protein coding gene Chr6:29172127-29187276 (+)
DBA/2J MGP_DBA2J_G0030345
 protein coding gene Chr6:26116157-26131399 (+)
FVB/NJ MGP_FVBNJ_G0030299
 protein coding gene Chr6:25870069-25885220 (+)
LP/J MGP_LPJ_G0030432
 protein coding gene Chr6:27460431-27475774 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030335
 protein coding gene Chr6:31673345-31689235 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030994
 protein coding gene Chr6:26906908-26923105 (+)
PWK/PhJ MGP_PWKPhJ_G0029339
 protein coding gene Chr6:25648856-25664339 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029175
 protein coding gene Chr6:26628524-26643759 (+)
WSB/EiJ MGP_WSBEiJ_G0029701
 protein coding gene Chr6:26878681-26893814 (+)



Homology
more
  • Human Ortholog
    IRF5, interferon regulatory factor 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRF5, interferon regulatory factor 5
  • Synonyms
    SLEB10
  • Links
    NCBI Gene ID: 3663
    neXtProt AC: NX_Q13568
    UniProt: Q13568

  • Chr Location
    7q32.1; chr7:128937032-128950038 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human IRF5 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 4 alleles in 5 genetic backgrounds
    10 phenotypes from multigenic genotypes
    88 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit resistance to lethal shock with a marked decrease in the serum levels of proinflammatory cytokines, but normal B cell development. Mice homozygous for another allele are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    771
  • Tissues
    58
  • cDNA Data
    33
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029771 Ensembl Gene Model | MGI Sequence Detail 15247 C57BL/6J ±  kb
    transcript ENSMUST00000004392 Ensembl | MGI Sequence Detail 2189 Not Applicable  
    polypeptide ENSMUSP00000004392 Ensembl | MGI Sequence Detail 497 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000002047 interferon regulatory factor 5
      (term hierarchy)
    • InterPro Domains
      IPR019471 Interferon regulatory factor-3
      IPR019817 Interferon regulatory factor, conserved site
      IPR001346 Interferon regulatory factor, DNA-binding domain
      IPR008984 SMAD/FHA domain superfamily
      IPR017855 SMAD-like domain superfamily
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    • GlyGen
      P56477 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 34

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141682
    References
    more
    • Summaries
      All 145
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 88
    • Earliest
      J:61896 Lee YJ, et al., Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). FEBS Lett. 2000 Apr 28;472(2-3):230-4
    • Latest
      J:347749 Pereira M, et al., The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection. Cell Rep. 2024 Feb 27;43(2):113795
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory