Irf5 MGI Mouse Gene Detail - MGI:1350924 - interferon regulatory factor 5

Symbol

Irf5
Name

interferon regulatory factor 5
Synonyms

mirf5

Feature Type

protein coding gene
IDs

MGI:1350924
NCBI Gene: 27056
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr6:29526624-29541870 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 12.36 cM
Mapping Data

3 experiments

SNPs within 2kb

378 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1350924	protein coding gene	Chr6:29526129-29541874 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030527	protein coding gene	Chr6:27329837-27346367 (+)
A/J	MGP_AJ_G0030500	protein coding gene	Chr6:26168519-26183668 (+)
AKR/J	MGP_AKRJ_G0030427	protein coding gene	Chr6:27031368-27046508 (+)
BALB/cJ	MGP_BALBcJ_G0030510	protein coding gene	Chr6:26325726-26341030 (+)
C3H/HeJ	MGP_C3HHeJ_G0030223	protein coding gene	Chr6:27031153-27047065 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030964	protein coding gene	Chr6:28112030-28127275 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028175	protein coding gene	Chr6:24377161-24392940 (+)
CAST/EiJ	MGP_CASTEiJ_G0029625	protein coding gene	Chr6:26834612-26850869 (+)
CBA/J	MGP_CBAJ_G0030201	protein coding gene	Chr6:29172127-29187276 (+)
DBA/2J	MGP_DBA2J_G0030345	protein coding gene	Chr6:26116157-26131399 (+)
FVB/NJ	MGP_FVBNJ_G0030299	protein coding gene	Chr6:25870069-25885220 (+)
LP/J	MGP_LPJ_G0030432	protein coding gene	Chr6:27460431-27475774 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030335	protein coding gene	Chr6:31673345-31689235 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030994	protein coding gene	Chr6:26906908-26923105 (+)
PWK/PhJ	MGP_PWKPhJ_G0029339	protein coding gene	Chr6:25648856-25664339 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029175	protein coding gene	Chr6:26628524-26643759 (+)
WSB/EiJ	MGP_WSBEiJ_G0029701	protein coding gene	Chr6:26878681-26893814 (+)

Human Ortholog

IRF5, interferon regulatory factor 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IRF5, interferon regulatory factor 5
Synonyms

SLEB10
Links

HGNC:6120

NCBI Gene ID: 3663

neXtProt AC: NX_Q13568

UniProt: Q13568
Chr Location

7q32.1; chr7:128937032-128950038 (+) GRCh38

MGI Vertebrate Homology

Irf5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IRF5
Gene Tree

Irf5

Diseases

5 with human IRF5 associations

				Human Disease	Mouse Models
				herpes simplex IDs herpes simplex DOID:8566 DOID:8763 DOID:9012 DOID:9239 ICD10CM:B00.9 ICD9CM:054 MESH:D006561 NCI:C155871 UMLS_CUI:C0019348
				inflammatory bowel disease 14 IDs inflammatory bowel disease 14 DOID:0110895 MESH:C567383 OMIM:612245
				multiple sclerosis IDs multiple sclerosis DOID:2377 ICD10CM:G35 ICD9CM:340 MESH:D009103 NCI:C3243 OMIM:612594 OMIM:612595 OMIM:612596 UMLS_CUI:C0026769
				rheumatoid arthritis IDs rheumatoid arthritis DOID:7148 EFO:0000685 ICD10CM:M06.9 ICD9CM:714.0 KEGG:05323 MESH:D001172 NCI:C2884 OMIM:180300 UMLS_CUI:C0003873
				systemic lupus erythematosus IDs systemic lupus erythematosus DOID:9074 ICD10CM:M32.9 ICD9CM:710.0 KEGG:05322 MESH:D008180 NCI:C3201 OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 ORDO:536 UMLS_CUI:C0024141

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 4 alleles in 5 genetic backgrounds
10 phenotypes from multigenic genotypes
88 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

5
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice exhibit resistance to lethal shock with a marked decrease in the serum levels of proinflammatory cytokines, but normal B cell development. Mice homozygous for another allele are viable and fertile.

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All GO Annotations

40
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

771
Tissues

58
cDNA Data

33
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase irf5

ZFIN irf5

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All Sequences

66
RefSeq

18
UniProt

6
CCDS

CCDS19962.1, CCDS80504.1

Ensembl

ENSMUSG00000029771 (Evidence)
NCBI Gene

27056

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029771	Ensembl Gene Model \| MGI Sequence Detail	15247	C57BL/6J	± kb
transcript	ENSMUST00000004392	Ensembl \| MGI Sequence Detail	2189	Not Applicable
polypeptide	ENSMUSP00000004392	Ensembl \| MGI Sequence Detail	497	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000002047 interferon regulatory factor 5

(term hierarchy)
InterPro Domains

IPR019471 Interferon regulatory factor-3

IPR019817 Interferon regulatory factor, conserved site

IPR001346 Interferon regulatory factor, DNA-binding domain

IPR008984 SMAD/FHA domain superfamily

IPR017855 SMAD-like domain superfamily

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

P56477 1 site, 1 O-linked glycan (1 site)

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All nucleic 34

cDNA 34

Microarray probesets 3

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MGI:2141682

Summaries

All 145

Developmental Gene Expression 7

Gene Ontology 10

Phenotypes 88
Earliest

J:61896 Lee YJ, et al., Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). FEBS Lett. 2000 Apr 28;472(2-3):230-4
Latest

J:347749 Pereira M, et al., The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection. Cell Rep. 2024 Feb 27;43(2):113795

TSS for Irf5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr55266	Chr6:29526089-29526157 (+)	-501 bp
Tssr55267	Chr6:29526664-29526675 (+)	46 bp
Tssr55268	Chr6:29526683-29526684 (+)	60 bp
Tssr55269	Chr6:29526689-29526723 (+)	82 bp
Tssr55270	Chr6:29526740-29526751 (+)	122 bp
Tssr55271	Chr6:29528059-29528115 (+)	1,463 bp
Tssr55272	Chr6:29529276-29529295 (+)	2,662 bp
Tssr55273	Chr6:29529307-29529324 (+)	2,692 bp
Tssr55274	Chr6:29531150-29531171 (+)	4,537 bp
Tssr55275	Chr6:29531257-29531269 (+)	4,639 bp
Tssr55276	Chr6:29534008-29534024 (+)	7,392 bp
Tssr55277	Chr6:29534061-29534087 (+)	7,450 bp
Tssr55278	Chr6:29535371-29535382 (+)	8,753 bp
Tssr55279	Chr6:29536027-29536063 (+)	9,421 bp
Tssr55280	Chr6:29537058-29537075 (+)	10,443 bp
Tssr55281	Chr6:29540886-29540890 (+)	14,264 bp
Tssr55282	Chr6:29540976-29540982 (+)	14,355 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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