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Cartpt Gene Detail
Summary
  • Symbol
    Cartpt
  • Name
    CART prepropeptide
  • Synonyms
    Cart
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351330
    NCBI Gene: 27220
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:100034991-100037191 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 52.90 cM, cytoband D1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351330
 protein coding gene Chr13:100034991-100037599 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020877
 protein coding gene Chr13:101713276-101716419 (-)
A/J MGP_AJ_G0020831
 protein coding gene Chr13:97796337-97798423 (-)
AKR/J MGP_AKRJ_G0020805
 protein coding gene Chr13:100796008-100798206 (-)
BALB/cJ MGP_BALBcJ_G0020829
 protein coding gene Chr13:98505204-98507322 (-)
C3H/HeJ MGP_C3HHeJ_G0020620
 protein coding gene Chr13:100512118-100514332 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021263
 protein coding gene Chr13:104721774-104725773 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018832
 protein coding gene Chr13:93523963-93526128 (-)
CAST/EiJ MGP_CASTEiJ_G0020138
 protein coding gene Chr13:99953010-99956914 (-)
CBA/J MGP_CBAJ_G0020580
 protein coding gene Chr13:108901823-108905978 (-)
DBA/2J MGP_DBA2J_G0020705
 protein coding gene Chr13:97569812-97572283 (-)
FVB/NJ MGP_FVBNJ_G0020686
 protein coding gene Chr13:96312723-96314919 (-)
LP/J MGP_LPJ_G0020780
 protein coding gene Chr13:101805960-101808099 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020714
 protein coding gene Chr13:109158875-109162511 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021304
 protein coding gene Chr13:100244648-100248004 (-)
PWK/PhJ MGP_PWKPhJ_G0019891
 protein coding gene Chr13:96399294-96401999 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019714
 protein coding gene Chr13:96467025-96529432 (-)
WSB/EiJ MGP_WSBEiJ_G0020196
 protein coding gene Chr13:100678609-100680762 (-)



Homology
more
  • Human Ortholog
    CARTPT, CART prepropeptide
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CARTPT, CART prepropeptide
  • Synonyms
    CART
  • Links
    NCBI Gene ID: 9607
    neXtProt AC: NX_Q16568
    UniProt: Q16568

  • Chr Location
    5q13.2; chr5:71719275-71721048 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CARTPT associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 4 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit increases in food consumption, body weight, and fat mass when fed a high-fat diet, but not on a regular diet. Mice homozygous for another disruption in this gene have increased body weight at older ages, impaired insulin secretion and glucose intolerance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    897
  • Tissues
    61
  • cDNA Data
    13
  • Literature Summary
    39
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27220 NCBI Gene Model | MGI Sequence Detail 2201 C57BL/6J ±  kb
    transcript NM_013732 RefSeq | MGI Sequence Detail 875 Not Specified  
    polypeptide P56388 UniProt | EBI | MGI Sequence Detail 129 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 14
      Primer pair 1
      Other 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 39
      Gene Ontology 12
      Phenotypes 34
    • Earliest
      J:47476 Kristensen P, et al., Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature. 1998 May 7;393(6680):72-6
    • Latest
      J:354454 De Vincenti AP, et al., Lrig1 regulates cell fate specification of glutamatergic neurons via FGF-driven Jak2/Stat3 signaling in cortical progenitors. Development. 2024 Sep 1;151(17):dev202879
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory