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Azi2 Gene Detail
Summary
  • Symbol
    Azi2
  • Name
    5-azacytidine induced gene 2
  • Synonyms
    AZ2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351332
    NCBI Gene: 27215
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:117869567-117898862 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 69.86 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    796 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351332
 protein coding gene Chr9:117869510-117898866 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035403
 protein coding gene Chr9:120696040-120728082 (+)
A/J MGP_AJ_G0035383
 protein coding gene Chr9:116245712-116276839 (+)
AKR/J MGP_AKRJ_G0035316
 protein coding gene Chr9:119224239-119255007 (+)
BALB/cJ MGP_BALBcJ_G0035379
 protein coding gene Chr9:116097407-116128749 (+)
C3H/HeJ MGP_C3HHeJ_G0035087
 protein coding gene Chr9:119726491-119756851 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035902
 protein coding gene Chr9:124013183-124045699 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032785
 protein coding gene Chr9:113462009-113492356 (+)
CAST/EiJ MGP_CASTEiJ_G0034391
 protein coding gene Chr9:119653371-119690242 (+)
CBA/J MGP_CBAJ_G0035054
 protein coding gene Chr9:128635776-128672613 (+)
DBA/2J MGP_DBA2J_G0035213
 protein coding gene Chr9:115696885-115726550 (+)
FVB/NJ MGP_FVBNJ_G0035160
 protein coding gene Chr9:114531587-114566088 (+)
LP/J MGP_LPJ_G0035292
 protein coding gene Chr9:121039350-121072682 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035201
 protein coding gene Chr9:129718712-129752373 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035921
 protein coding gene Chr9:119615576-119646037 (+)
PWK/PhJ MGP_PWKPhJ_G0034098
 protein coding gene Chr9:116068529-116098096 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033932
 protein coding gene Chr9:119714786-119746703 (+)
WSB/EiJ MGP_WSBEiJ_G0034512
 protein coding gene Chr9:119525805-119560292 (+)



Homology
more
  • Human Ortholog
    AZI2, 5-azacytidine induced 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AZI2, 5-azacytidine induced 2
  • Synonyms
    AZ2, NAP1, TILP
  • Links
    NCBI Gene ID: 64343
    neXtProt AC: NX_Q9H6S1
    UniProt: Q9H6S1

  • Chr Location
    3p24.1; chr3:28315003-28349050 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired GM-CSF-derived bone marrow-derived dendritic cell differenatiation, cytokine response and ability to stimulate T cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    20
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    27
  • cDNA Data
    19
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039285 Ensembl Gene Model | MGI Sequence Detail 29296 C57BL/6J ±  kb
transcript ENSMUST00000133580 Ensembl | MGI Sequence Detail 2156 Not Applicable  
polypeptide ENSMUSP00000118765 Ensembl | MGI Sequence Detail 405 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 21

    Microarray probesets 5
Other
Accession IDs
less
MGI:2146344
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:20478 Hutchison JB, et al., Brain formation of oestrogen in the mouse: sex dimorphism in aromatase development. J Steroid Biochem Mol Biol. 1994 Jun;49(4-6):407-15
  • Latest
    J:258682 Parker CC, et al., Genome-wide association study of behavioral, physiological and gene expression traits in outbred CFW mice. Nat Genet. 2016 Aug;48(8):919-26
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory