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G3bp1 Gene Detail
Summary
  • Symbol
    G3bp1
  • Name
    G3BP stress granule assembly factor 1
  • Synonyms
    GAP SH3 binding protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351465
    NCBI Gene: 27041
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:55360521-55391722 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 33.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    781 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351465
 protein coding gene Chr11:55360511-55395664 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018332
 protein coding gene Chr11:55005736-55043198 (+)
A/J MGP_AJ_G0018301
 protein coding gene Chr11:52957214-52993779 (+)
AKR/J MGP_AKRJ_G0018270
 protein coding gene Chr11:54682655-54720108 (+)
BALB/cJ MGP_BALBcJ_G0018272
 protein coding gene Chr11:53280931-53322683 (+)
C3H/HeJ MGP_C3HHeJ_G0018083
 protein coding gene Chr11:54616075-54648431 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018724
 protein coding gene Chr11:56667525-56705999 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016374
 protein coding gene Chr11:50370719-50405891 (+)
CAST/EiJ MGP_CASTEiJ_G0017648
 protein coding gene Chr11:54657028-54686299 (+)
CBA/J MGP_CBAJ_G0018058
 protein coding gene Chr11:59365282-59405421 (+)
DBA/2J MGP_DBA2J_G0018167
 protein coding gene Chr11:52637328-52672725 (+)
FVB/NJ MGP_FVBNJ_G0018159
 protein coding gene Chr11:52305414-52341538 (+)
LP/J MGP_LPJ_G0018242
 protein coding gene Chr11:55465777-55501666 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018185
 protein coding gene Chr11:60540203-60576446 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018766
 protein coding gene Chr11:54702633-54748359 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0017216
 protein coding gene Chr11:54492368-54534410 (+)
WSB/EiJ MGP_WSBEiJ_G0017696
 protein coding gene Chr11:54345953-54377098 (+)



Homology
more
  • Human Ortholog
    G3BP1, G3BP stress granule assembly factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    G3BP1, G3BP stress granule assembly factor 1
  • Synonyms
    G3BP, HDH-VIII
  • Links
    NCBI Gene ID: 10146
    neXtProt AC: NX_Q13283
    UniProt: Q13283

  • Chr Location
    5q33.1; chr5:151771045-151812911 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display perinatal lethality with severe cell death in the nervous system and decreased cell proliferation. Neonates from heterozygous null female mice display increased mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    897
  • Tissues
    159
  • cDNA Data
    14
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27041 NCBI Gene Model | MGI Sequence Detail 31202 C57BL/6J ±  kb
    transcript NM_001417587 RefSeq | MGI Sequence Detail 3112 C57BL/6  
    polypeptide P97855 UniProt | EBI | MGI Sequence Detail 465 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 15
      Primer pair 9
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2144303, MGI:2144694
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 13
      Phenotypes 28
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory